Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions

doi:10.1016/j.intimp.2008.05.001

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	Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions
	Wan, Jin 1; Zhu, Yi-Na 1; Feng, Jia-Quan 1; Chen, Hai-Jun 1; Zhang, Ru-Jun 1; Ni, Jia 1; Chen, Zhen-Hua 1; Hou, Li-Fei 1; Liu, Quan-Fang 1; Zhang, Jing 1
刊名	INTERNATIONAL IMMUNOPHARMACOLOGY
	2008-09
卷号	8 期号:9 页码:1248-1256
关键词	P. sepium bge PSA ConA-induced hepatitis NKT cell
ISSN号	1567-5769
DOI	10.1016/j.intimp.2008.05.001
文献子类	Article
英文摘要	Periploca sepium Bge, a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis in china. Periplocoside A (PSA), a pregnane glycoside, is a new nature product compound isolated from P. sepium Bge. We examined the protective effects of PSA, on concanavaline A (ConA)-induced hepatitis. Pretreatment with PSA dramatically ameliorated ConA-induced liver injury, which was characterized by reducing serum alanine transaminase (ALT), pathogenic cytokines of interteukin (IL)-4 and interferon (IFN)-gamma levels, impeding the liver necrosis, and thus elevating the survival rate. In vitro, PSA inhibited IL-4 and IFN-gamma productions of alpha-galactosylceramide (alpha-GalCer) or anti-CD3-activated Natural killer T (NKT) cells. Enzyme Linked Immunosorbent Assay (ELISA) and Reverse Transcription Polymerase Chain Reaction (RTPCR) assays revealed PSA suppressed IL-4 transcription and IFN-gamma translation. In conclusion, PSA had significantly preventative effect on ConA-induced hepatitis, which was closely associated with inhibition of NKT-derived inflammatory cytokine productions. These findings suggested that PSA has the therapeutic potential for treatment of human autoimmune-related hepatitis. (c) 2008 Elsevier B.V. All rights reserved.
WOS关键词	TUMOR-NECROSIS-FACTOR ; CELL-MEDIATED HEPATITIS ; INDUCED LIVER-INJURY ; KILLER T-CELLS ; INTERFERON-GAMMA ; AUTOIMMUNE HEPATITIS ; IN-VIVO ; ACTIVATION ; LYMPHOCYTES ; CD4(+)
WOS研究方向	Immunology ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000258050400012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272821]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第一研究室
通讯作者	Zhao, Wei-Ming
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wan, Jin,Zhu, Yi-Na,Feng, Jia-Quan,et al. Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2008,8(9):1248-1256.
APA	Wan, Jin.,Zhu, Yi-Na.,Feng, Jia-Quan.,Chen, Hai-Jun.,Zhang, Ru-Jun.,...&Zuo, Jian-Ping.(2008).Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions.INTERNATIONAL IMMUNOPHARMACOLOGY,8(9),1248-1256.
MLA	Wan, Jin,et al."Periplocoside A, a pregnane glycoside from Periploca sepium Bge, prevents concanavalin A-induced mice hepatitis through inhibiting NKT-derived inflammatory cytokine productions".INTERNATIONAL IMMUNOPHARMACOLOGY 8.9(2008):1248-1256.