Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia

doi:10.1016/j.cbi.2009.04.049

	Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia
	Zhang, Hai Yan; Zheng, Chun Yan; Yan, Han; Wang, Zhi Fei; Tang, Li Li; Gao, Xin; Tang, Xi Can
刊名	CHEMICO-BIOLOGICAL INTERACTIONS
	2008-09-25
卷号	175 期号:1-3 页码:396-402
关键词	Alzheimer's disease Huperzine A Acetylcholinesterase inhibitor beta-Amyloid Mitochondrial dysfunction Inflammation
ISSN号	0009-2797
DOI	10.1016/j.cbi.2009.04.049
文献子类	Article; Proceedings Paper
英文摘要	Huperzine A (HupA), a novel Lycopodium alkaloid isolated from Chinese folk medicine Huperzia serrata (Qian Ceng Ta), is a potent, selective and well-tolerated inhibitor of acetylcholinesterase (AChE). It has been proven to significantly improve the learning and memory impairment in Alzheimer's disease (AD) and vascular dementia (VaD) patients in China. interestingly, Our recent data indicate that HupA also possesses other protective functions. This paper will give an overview on the protective effects of HupA,which includes regulating beta-amyloid precursor Protein (APP) metabolism, Protecting against A beta-mediated oxidative stress, apoptosis and mitochondrial dysfunction, as well as anti-inflammation. The multiple neuroprotective effects of HupA might yield additional beneficial effects in AD and VaD therapy. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
WOS关键词	AMYLOID-BETA-PEPTIDE ; RAT CORTICAL-NEURONS ; MUSCARINIC ACETYLCHOLINE-RECEPTORS ; PROTEIN-KINASE-C ; OXYGEN-GLUCOSE DEPRIVATION ; SWEDISH MUTANT-CELLS ; NERVE GROWTH-FACTOR ; PRECURSOR PROTEIN ; CHOLINESTERASE-INHIBITORS ; MITOCHONDRIAL DYSFUNCTION
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Toxicology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000260110500075
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272804]
专题	院士及顾问专家中科院受体结构与功能重点实验室新药研究国家重点实验室药理学第二研究室
通讯作者	Tang, Xi Can
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Hai Yan,Zheng, Chun Yan,Yan, Han,et al. Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia[J]. CHEMICO-BIOLOGICAL INTERACTIONS,2008,175(1-3):396-402.
APA	Zhang, Hai Yan.,Zheng, Chun Yan.,Yan, Han.,Wang, Zhi Fei.,Tang, Li Li.,...&Tang, Xi Can.(2008).Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia.CHEMICO-BIOLOGICAL INTERACTIONS,175(1-3),396-402.
MLA	Zhang, Hai Yan,et al."Potential therapeutic targets of huperzine A for Alzheimer's disease and vascular dementia".CHEMICO-BIOLOGICAL INTERACTIONS 175.1-3(2008):396-402.