Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant

doi:10.1016/j.tetlet.2017.02.044

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	Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant
	Xu, Fuwang 2; Xiao, Chengqian 1; Lv, Xue 1; Lei, Min1 ; Hu, Lihong 1,2,3
刊名	TETRAHEDRON LETTERS
	2017-03-29
卷号	58 期号:13 页码:1312-1315
关键词	Xanthanolide Mogolide D Mogolide E Xanthatin Xanthium mogolium Kitag
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2017.02.044
文献子类	Article
英文摘要	Two xanthanolide-type dimmers, namely Mogolide D (4) and Mogolide E (5) are isolated from the aerial parts of Xanthium mogolium Kitag plant collected from Heilongjiang province, China. The dimmers' relative structures are elucidated on the basis of HRESIMS, IR spectrum and NMR spectroscopy. The absolute configurations of them are assigned with ECD spectra. The biosynthetic pathway of the two dimmers is also proposed. Besides, Mogolide D (4) and Mogolide E (5) are tested against MDA-MB-231 breast cancer cell line with IC50 8.46 mu M and 19.20 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81473110] ; Special Fund for Strategic Pilot Technology Chinese Academy of Sciences[XDA12040303] ; Shanghai Science & Technology Support Program[13431900401]
WOS关键词	SESQUITERPENE LACTONES ; CARBAMATE DERIVATIVES ; CANCER-CELLS ; XANTHATIN ; INHIBITION ; DISCOVERY ; PATHWAY
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000397699400018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272735]
专题	上海中药现代化研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Lei, Min; Hu, Lihong
作者单位	1.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China; 2.East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China; 3.Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Sch Pharm, Jiangsu Key Lab Therapeut Mat Chinese Med, Nanjing, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Xu, Fuwang,Xiao, Chengqian,Lv, Xue,et al. Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant[J]. TETRAHEDRON LETTERS,2017,58(13):1312-1315.
APA	Xu, Fuwang,Xiao, Chengqian,Lv, Xue,Lei, Min,&Hu, Lihong.(2017).Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant.TETRAHEDRON LETTERS,58(13),1312-1315.
MLA	Xu, Fuwang,et al."Two new dimmeric xanthanolides isolated from Xanthiurn mogolium Kitag plant".TETRAHEDRON LETTERS 58.13(2017):1312-1315.