Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity

doi:10.1021/acs.jnatprod.6b01086

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 天然药物化学研究室

	Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity
	Niu, Biao 1,5,6,7; Ke, Chang-Qiang5,6 ; Li, Bo-Han 1,2; Li, Yuanyuan 4; Yi, Yongji 4; Luo, Yongwei 4; Shuai, Lin 1,2; Yao, Sheng5,6 ; Lin, Li-Gen 3; Li, Jia1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2017-05
卷号	80 期号:5 页码:1428-1435
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.6b01086
文献子类	Article
英文摘要	Seven new cucurbitane glucosides, 11-oxomogrosides III E and IV (1 and 2), 11-oxoisomogroside V (3), 7-oxomogrosides III E and W (4 and 5), and mogrosides VI A and VI B (6 and 7), were separated from the crude extract of Siraitia grosvenorii. The new structures were defined by analysis of their H-1 and C-13 NMR, 2D NMR, and HRESIMS data. Especially, the band-selective constant time HSQC and band-selective constant time HMBC techniques were recuited to elucidate the structures of the complex glucoside moieties. Using the PGC-la promoter driven luciferase reporter assay, the isolated compounds were examined for PGC-la promoter activity.
资助项目	National Science and Technology Major Project "Key New Drug Creation and Manufacturing Program"[2015ZX09103002] ; National Natural Science Funds of China[81673327] ; Science and Technology Commission of Shanghai Municipality[15DZ2291600] ; Guangxi Science and Technology Department[14125008-2-29] ; State Key Laboratory of Drug Research[SIMM1501ZZ-03] ; University of Macau[MYRG2014-00020-ICMS-QRCM] ; University of Macau[MYRG2015-00153-ICMS-QRCM]
WOS关键词	FRUCTUS MOMORDICAE ; GLYCOSIDES ; FRUITS ; CONSTITUENTS ; EXPRESSION ; METABOLISM ; DISEASE ; PGC-1 ; GENE
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000402498300024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272682]
专题	天然药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Ye, Yang
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 2.Chinese Acad Sci, Chinese Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, 189 Guoshoujing Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 3.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 4.Guilin Layn Nat Ingredients Corp, Guilin 541199, Peoples R China; 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 6.Chinese Acad Sci, Nat Prod Chem Dept, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China; 7.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China;
推荐引用方式 GB/T 7714	Niu, Biao,Ke, Chang-Qiang,Li, Bo-Han,et al. Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity[J]. JOURNAL OF NATURAL PRODUCTS,2017,80(5):1428-1435.
APA	Niu, Biao.,Ke, Chang-Qiang.,Li, Bo-Han.,Li, Yuanyuan.,Yi, Yongji.,...&Ye, Yang.(2017).Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity.JOURNAL OF NATURAL PRODUCTS,80(5),1428-1435.
MLA	Niu, Biao,et al."Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity".JOURNAL OF NATURAL PRODUCTS 80.5(2017):1428-1435.