Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer

doi:10.1002/adfm.201606530

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer
	Zhou, Fangyuan 1,2,3; Feng, Bing 1,2; Wang, Tingting 1,2; Wang, Dangge 1,2; Meng, Qingshuo 1,2; Zeng, Jianfeng 1,2,4; Zhang, Zhiwen1,2 ; Wang, Siling 1,2,3; Yu, Haijun1,2 ; Li, Yaping1,2
刊名	ADVANCED FUNCTIONAL MATERIALS
	2017-05-25
卷号	27 期号:20
ISSN号	1616-301X
DOI	10.1002/adfm.201606530
文献子类	Article
英文摘要	Nanomedicine is a promising approach for combination chemotherapy of triple-negative breast cancer (TNBC). However, the therapeutic efficacy of nanoparticulate drugs is suppressed by a series of biological barriers. The authors herein present a programmed stimuli-responsive liposomal vesicle to overcome the sequential barriers for enhanced TNBC therapy. The intelligent vesicles are engineered by integrating an enzyme-cleavable polyethylene glycol (PEG) corona, a light-responsive photosensitizer pheophorbide a (PPa), and a temperature-sensitive liposome (TSL) into a single nanoplatform. The resultant enzyme, light, and temperature multisensitive liposome (ELTSL) is sequentially coloaded with a lipophilic oxaliplatin prodrug of hexadecyloxaliplatin carboxylic acid (HOC) and hydrophilic doxorubicin hydrochloride (DOX). Dual drug-loaded ELTSL displays enhanced tumor penetration and increased cellular uptake upon matrix metalloproteinase 2 mediated cleavage of the PEG corona. Under NIR laser irradiation, PPa induces mild hyperthermia effect to trigger ultrafast drug release in the tumor cells. In combination with PPa-mediated photodynamic therapy, HOC and DOX coloaded ELTSL show significantly improved antitumor efficacy than monotherapy. Given the clinically translatable potential of the liposomal vesicles, ELTSL might represent a promising nanoplatform for combination TNBC therapy.
资助项目	National Basic Research Program of China[2013CB932704] ; National Natural Science Foundation of China[31622025] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[81521005] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120162002] ; Youth Innovation Promotion Association CAS[2014218]
WOS关键词	TEMPERATURE-SENSITIVE LIPOSOMES ; TRIGGERED DOXORUBICIN RELEASE ; PROLONGED CIRCULATION TIME ; DEMAND DRUG-RELEASE ; MILD HYPERTHERMIA ; IN-VIVO ; THERMOSENSITIVE LIPOSOMES ; POLYMERIC NANOPARTICLES ; OVARIAN-CANCER ; SOLID TUMORS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000401803400007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272654]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yu, Haijun; Li, Yaping
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China; 4.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Fangyuan,Feng, Bing,Wang, Tingting,et al. Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2017,27(20).
APA	Zhou, Fangyuan.,Feng, Bing.,Wang, Tingting.,Wang, Dangge.,Meng, Qingshuo.,...&Li, Yaping.(2017).Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer.ADVANCED FUNCTIONAL MATERIALS,27(20).
MLA	Zhou, Fangyuan,et al."Programmed Multiresponsive Vesicles for Enhanced Tumor Penetration and Combination Therapy of Triple-Negative Breast Cancer".ADVANCED FUNCTIONAL MATERIALS 27.20(2017).