Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries

doi:10.1021/acs.orglett.7b01297

	Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries
	Fan, Zhoulong 2,3,4; Li, Jie 5; Lu, Heng 5; Wang, Dong-Yu 2,3; Wang, Chao 1,6; Uchiyama, Masanobu 1,6; Zhang, Ao2,3,4,5
刊名	ORGANIC LETTERS
	2017-06-16
卷号	19 期号:12 页码:3199-3202
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b01297
文献子类	Article
英文摘要	A removable oxime-assisted meta-C-H nitration of arenes is reported. Mechanistic investigations and DFT calculations reveal a new monomeric octahedral ruthenium(II) complex is responsible for the meta-selective nitration. Dioxygen as a cooxidant is crucial for achieving high conversion and good yields. Moreover, the utility of the present reaction protocol is further showcased by the late-stage modification of the clinical CNS drugs Diazepam and Fluvoxamine.
资助项目	Chinese NSF[81373277] ; Chinese NSF[81430080] ; National Program on Key Basic Research Project of China[2015CB910603] ; International Cooperative Program[GJHZ1622] ; Key Program of the Frontier Science of the Chinese Academy of Sciences[160621] ; Shanghai Commission of Science and Technology[16XD1404600] ; Shanghai Commission of Science and Technology[14431905300] ; Shanghai Commission of Science and Technology[14431900400] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YKF-08] ; CAS Key Laboratory of Receptor Research of SIMM[SIMM1606YZZ-06]
WOS关键词	AROMATIC-SUBSTITUTION REACTIONS ; ORTHO-METALATION STRATEGY ; FUNCTIONALIZATION ; BROMINATION ; ALKYLATION ; ACTIVATION ; REGIOSELECTIVITY ; SULFONATION ; LIGANDS ; BONDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000403854300041
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272604]
专题	药物化学研究室中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Zhang, Ao
作者单位	1.RIKEN Ctr Sustainable Resource Sci & Elements Che, Adv Elements Chem Res Team, Wako, Saitama 3510198, Japan 2.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China; 3.Chinese Acad Sci, SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 5.ShanghaiTech Univ, Shanghai 201210, Peoples R China; 6.Univ Tokyo, Grad Sch Pharmaceut Sci, Tokyo 1130033, Japan;
推荐引用方式 GB/T 7714	Fan, Zhoulong,Li, Jie,Lu, Heng,et al. Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries[J]. ORGANIC LETTERS,2017,19(12):3199-3202.
APA	Fan, Zhoulong.,Li, Jie.,Lu, Heng.,Wang, Dong-Yu.,Wang, Chao.,...&Zhang, Ao.(2017).Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries.ORGANIC LETTERS,19(12),3199-3202.
MLA	Fan, Zhoulong,et al."Monomeric Octahedral Ruthenium(II) Complex Enabled meta-C-H Nitration of Arenes with Removable Auxiliaries".ORGANIC LETTERS 19.12(2017):3199-3202.