Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba

doi:10.1016/j.fitote.2017.09.006

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	Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba
	Huang, Qing-Hua 1; Lei, Chun 1; Wang, Pei-Pei2 ; Li, Jing-Ya2 ; Li, Jia2 ; Hou, Ai-Jun 1
刊名	FITOTERAPIA
	2017-10
卷号	122 页码:138-143
关键词	Morus alba Moraceae Isoprenylated phenolics Albasins A-D Protein tyrosine phosphatase 1B
ISSN号	0367-326X
DOI	10.1016/j.fitote.2017.09.006
文献子类	Article
英文摘要	Two new Diels-Alder adducts, albasins A and B (1 and 2), one new isoprenylated 2-arylbenzofuran, albasin C (3), one new isoprenylated flavone, albasin D (4), together with sixteen known phenolic compounds, were isolated from the root bark of Morus alba. Their structures were elucidated by extensive spectroscopic analysis, including NMR, MS, and ECD data. All the new compounds and most of the known ones showed significant inhibitory effects on PTP1B in vitro with IC50 values ranging from 0.57 to 7.49 mu M.
资助项目	National Natural Science Foundation of China[21372049] ; National Natural Science Foundation of China[81222045] ; Shanghai Commission of Science and Technology[14431905400] ; National Key Research and Development Program of China[2016YFC1305500]
WOS关键词	CULTIVATED MULBERRY TREE ; ALDER TYPE ADDUCTS ; TYROSINE-PHOSPHATASE 1B ; ROOT BARK ; 2-ARYLBENZOFURAN DERIVATIVES ; CALLUS-CULTURE ; LHOU KOIDZ ; CONSTITUENTS ; KUWANON ; FLAVONOIDS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000413383500024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272467]
专题	药理学第三研究室中科院受体结构与功能重点实验室新药研究国家重点实验室药物安全性评价中心国家新药筛选中心
通讯作者	Hou, Ai-Jun
作者单位	1.Fudan Univ, Dept Phannacognosy, Sch Pharm, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Huang, Qing-Hua,Lei, Chun,Wang, Pei-Pei,et al. Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba[J]. FITOTERAPIA,2017,122:138-143.
APA	Huang, Qing-Hua,Lei, Chun,Wang, Pei-Pei,Li, Jing-Ya,Li, Jia,&Hou, Ai-Jun.(2017).Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba.FITOTERAPIA,122,138-143.
MLA	Huang, Qing-Hua,et al."Isoprenylated phenolic compounds with PTP1B inhibition from Morus alba".FITOTERAPIA 122(2017):138-143.