Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer

doi:10.1038/aps.2017.74

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	Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer
	Dong, Xin-yue 3; Lang, Tian-qun 1,2; Yin, Qi1,2 ; Zhang, Peng-cheng1,2 ; Li, Ya-ping1,2
刊名	ACTA PHARMACOLOGICA SINICA
	2017-12
卷号	38 期号:12 页码:1655-1662
关键词	pH-sensitive polymer co-delivery micelle docetaxel silibinin breast cancer mouse breast cancer cell line 4T1 metastasis
ISSN号	1671-4083
DOI	10.1038/aps.2017.74
文献子类	Article
英文摘要	Breast cancer is the most vicious killer for women, and tumor metastasis is one of the leading causes of breast cancer therapy failure. In this study, a new pH-sensitive polymer (polyethylene glycol-block-poly[(1,4-butanediol)-diacrylate-beta-N, N-diisopropylethylenediamine], BDP) was synthesized. Based on BDP, docetaxel/ silibinin co-delivery micelles (DSMs) was constructed. DSM had a well-defined spherical shape under the transmission electron microscope with average hydrodynamic diameter of 85.3 +/- 0.4 nm, and were stable in the bloodstream but could dissociate to release the chemotherapeutic agents in the low pH environment of the endo/ lysosomes in the tumor cells. Compared with free drugs, DSM displayed greatly enhanced cellular uptake, higher cytotoxicity and a stronger antimetastasis effect against mouse breast cancer cell line 4T1. In 4T1 tumor-bearing mice treated with DSM (twice a week for 3 weeks), the inhibition rate on tumor growth and metastasis reached 71.9% and 80.1%, respectively. These results reveal that DSM might be a promising drug delivery system for metastatic breast cancer therapy.
资助项目	National Basic Research Program of China[2014CB931900] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81230029] ; Youth Innovation Promotion Association of CAS[2015226]
WOS关键词	ANTICANCER EFFICACY ; POLYMERIC MICELLES ; TUMOR-METASTASIS ; CELLULAR UPTAKE ; LUNG-CANCER ; IN-VITRO ; CELLS ; NANOPARTICLES ; DOXORUBICIN ; NANOCARRIERS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
CSCD记录号	CSCD:6136214
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:000416938000007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272369]
专题	药物制剂研究中心中科院受体结构与功能重点实验室新药研究国家重点实验室
通讯作者	Yin, Qi; Li, Ya-ping
作者单位	1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 3.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China;
推荐引用方式 GB/T 7714	Dong, Xin-yue,Lang, Tian-qun,Yin, Qi,et al. Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer[J]. ACTA PHARMACOLOGICA SINICA,2017,38(12):1655-1662.
APA	Dong, Xin-yue,Lang, Tian-qun,Yin, Qi,Zhang, Peng-cheng,&Li, Ya-ping.(2017).Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer.ACTA PHARMACOLOGICA SINICA,38(12),1655-1662.
MLA	Dong, Xin-yue,et al."Co-delivery of docetaxel and silibinin using pH-sensitive micelles improves therapy of metastatic breast cancer".ACTA PHARMACOLOGICA SINICA 38.12(2017):1655-1662.