Cascarinoids A-C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides

doi:10.1021/acs.orglett.7b03592

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	Cascarinoids A-C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides
	Gao, Xin-Hua 2,3; Xu, Yan-Sheng 1; Fan, Yao-Yue 2; Gan, Li-She 4; Zuo, Jian-Ping1,2 ; Yue, Jian-Min2
刊名	ORGANIC LETTERS
	2018-01-05
卷号	20 期号:1 页码:228-231
ISSN号	1523-7060
DOI	10.1021/acs.orglett.7b03592
文献子类	Article
英文摘要	Cascarinoids A-C (1-3), a new class of diterpenoid alkaloids with unpredicted conformations, were isolated and structurally characterized from Croton cascarilloides. It was demonstrated that the dispersion interaction might be one of the main contributors that stabilized the folded conformations for compounds 1-3. Compounds 2 and 3 showed moderate immunosuppressive activity against T and/or B lymphocyte cells.
资助项目	National Natural Science Foundation of the People's Republic of China[21532007] ; National Natural Science Foundation of the People's Republic of China[U1302222]
WOS关键词	CROTOFOLANE-TYPE DITERPENOIDS ; PHYLLANTHUS-HAINANENSIS ; DISPERSION INTERACTIONS ; STEMS ; IMMUNOSUPPRESSION ; EUPHORBIACEAE ; IVORENOLIDE ; MACROLIDE ; GLYCOSIDE ; SKELETON
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000419749700059
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272289]
专题	药理学第一研究室中科院受体结构与功能重点实验室新药研究国家重点实验室天然药物化学研究室
通讯作者	Zuo, Jian-Ping; Yue, Jian-Min
作者单位	1.Shanghai Univ Tradit Chinese Med, Lab Immunol & Virol, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China; 4.Zhejiang Univ, Coll Pharmaceut Sci, Inst Modern Chinese Med, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Gao, Xin-Hua,Xu, Yan-Sheng,Fan, Yao-Yue,et al. Cascarinoids A-C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides[J]. ORGANIC LETTERS,2018,20(1):228-231.
APA	Gao, Xin-Hua,Xu, Yan-Sheng,Fan, Yao-Yue,Gan, Li-She,Zuo, Jian-Ping,&Yue, Jian-Min.(2018).Cascarinoids A-C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides.ORGANIC LETTERS,20(1),228-231.
MLA	Gao, Xin-Hua,et al."Cascarinoids A-C, a Class of Diterpenoid Alkaloids with Unpredicted Conformations from Croton cascarilloides".ORGANIC LETTERS 20.1(2018):228-231.