COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL

doi:10.1038/clpt.1993.10

	COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL
	COUTINHO, EM ; DESOUZA, JC ; DASILVA, AR ; DEACOSTA, OM ; ALVAREZ, F ; BRACHE, V ; FLORES, JG ; VASQUEZESTRADA, L ; SANTO, R ; BASSOL, S
刊名	CLINICAL PHARMACOLOGY & THERAPEUTICS
	1993-01
卷号	53 期号:1 页码:65-75
ISSN号	0009-9236
DOI	10.1038/clpt.1993.10
文献子类	Article
英文摘要	The efficacy and acceptability of two widely used oral contraceptive tablets, one containing 250 mg levonorgestrel and 50 mug ethinyl estradiol and the other containing 150 mug desogestrel and 30 mug ethinyl estradiol, administered by the vaginal route were compared in 1055 women studied over 12,630 woman-months of vaginal contraceptive pill use. This multicenter clinical trial was performed in nine countries of the developing world by the ''South to South Cooperation in Reproductive Health,'' an organization founded by scientists from the Third World working in the area of reproductive health, and the study was developed and coordinated by one of these centers. The findings of this study confirm the efficacy of both these tablets when administered by the vaginal route. Involuntary pregnancy rates at 1 year of 2.78 for subjects in the levonorgestrel group and 4.54 for subjects the desogestrel group showed no statistically significant difference between the two groups. However, total discontinuation rates of 47.01 for subjects in the levonorgestrel group and 56.33 for subjects in the desogestrel group showed a statistically significant difference between the two groups, and discontinuation rates attributable able to prolonged bleeding of 0.6 for subjects in the levonorgestrel group and 3.2 for subjects in the desogestrel group were also significantly higher in the group of subjects using the desogestrel vaginal contraceptive pill. Blood pressure remained at admission values throughout treatment. A statistically significant weight increase from admission values occurred in both groups of subjects.
WOS关键词	MULTI-CENTER ; ESTRADIOL ; RINGS ; NORGESTREL
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	MOSBY-YEAR BOOK INC
WOS记录号	WOS:A1993KK06600010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275142]
专题	中国科学院上海药物研究所
通讯作者	COUTINHO, EM
作者单位	1.SHANGHAI INST MAT MED,SHANGHAI,PEOPLES R CHINA 2.CINSERHA PROFAMILIA,SANTO DOMINGO,DOMINICAN REP 3.ROCKEFELLER FDN,NEW YORK,NY 10036 4.UNIV ASSIUT,DEPT OBSTET & GYNECOL,ASSIUT,EGYPT 5.UNIV ZAMBIA,DEPT OBSTET & GYNECOL,LUSAKA,ZAMBIA 6.INST NACL NUTR SALVADOR ZUBIRAN,DEPT REPROD BIOL,MEXICO CITY 14000,DF,MEXICO 7.INST NACL ENDOCRINOL,HAVANA,CUBA 8.UNIV NAIROBI,DEPT OBSTET & GYNECOL,NAIROBI,KENYA 9.UNIV IBADAN,DEPT OBSTET & GYNECOL,IBADAN,NIGERIA
推荐引用方式 GB/T 7714	COUTINHO, EM,DESOUZA, JC,DASILVA, AR,et al. COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS,1993,53(1):65-75.
APA	COUTINHO, EM.,DESOUZA, JC.,DASILVA, AR.,DEACOSTA, OM.,ALVAREZ, F.,...&SEGAL, SJ.(1993).COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL.CLINICAL PHARMACOLOGY & THERAPEUTICS,53(1),65-75.
MLA	COUTINHO, EM,et al."COMPARATIVE-STUDY ON THE EFFICACY AND ACCEPTABILITY OF 2 CONTRACEPTIVE PILLS ADMINISTERED BY THE VAGINAL ROUTE - AN INTERNATIONAL MULTICENTER CLINICAL-TRIAL".CLINICAL PHARMACOLOGY & THERAPEUTICS 53.1(1993):65-75.