GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX

doi:10.1016/0304-3940(95)11993-7

	GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX
	CHEN, W ; ZHANG, JJ ; HU, GY ; WU, CP
刊名	NEUROSCIENCE LETTERS
	1995-09-29
卷号	198 期号:2 页码:123-126
关键词	FEEDBACK INHIBITION GAMMA-AMINOBUTYRIC ACID GABA(A) RECEPTOR RECURRENT COLLATERAL PYRAMIDAL NEURON MOTOR CORTEX CAT
ISSN号	0304-3940
DOI	10.1016/0304-3940(95)11993-7
文献子类	Article
英文摘要	Feedback or recurrent inhibition is generally proposed as a basic component of circuit organization in the brain. However, there is little direct evidence for its existence in the cortex, nor for the nature of the neurotransmitters and receptors involved. Here we address this issue by analyzing the potentials following a single action potential in cat neocortical pyramidal neurons. Using 3 M KCl-filled electrodes, we observed a distinct depolarizing potential that was superimposed on the spike after-potentials in seven out of 81 recorded neurons. This depolarizing potential had a latency of 4.4 +/- 1.6 ms and an amplitude of 4.8 +/- 2.1 mV. Its short risetime (1.39 +/- 0.27 ms) and the resemblance between its falling phase and the passive decay of membrane potential suggested that the depolarizing potential originated from the cell body or proximal dendrites. This potential was blocked by bicuculline methiodide (10 mu M), but not by phaclofen (0.2mM), suggesting that it was a reversed recurrent IPSP mediated by GABA(A) receptors.
WOS关键词	POSTSYNAPTIC POTENTIALS ; CELLS ; INTERNEURONS ; STIMULATION ; PATHWAYS ; INVITRO
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCI PUBL IRELAND LTD
WOS记录号	WOS:A1995TA40600014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275025]
专题	中国科学院上海药物研究所
作者单位	1.CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA 2.CHINESE ACAD SCI,SHANGHAI BRAIN RES INST,SHANGHAI 200031,PEOPLES R CHINA
推荐引用方式 GB/T 7714	CHEN, W,ZHANG, JJ,HU, GY,et al. GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX[J]. NEUROSCIENCE LETTERS,1995,198(2):123-126.
APA	CHEN, W,ZHANG, JJ,HU, GY,&WU, CP.(1995).GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX.NEUROSCIENCE LETTERS,198(2),123-126.
MLA	CHEN, W,et al."GABA(A) RECEPTOR-MEDIATED FEEDBACK INHIBITION IN PYRAMIDAL NEURONS OF CAT MOTOR CORTEX".NEUROSCIENCE LETTERS 198.2(1995):123-126.