Effect of (+/-)12-chloroscoulerine on brain dopamine receptors

	Effect of (+/-)12-chloroscoulerine on brain dopamine receptors
	Chen, LJ; Xi, Y; Pang, DW; Zhou, QT; Jin, GZ
刊名	ACTA PHARMACOLOGICA SINICA
	1996-03
卷号	17 期号:2 页码:185-189
关键词	(+/-)12-chloroscoulerine dopamine receptors (-)stepholidine catalepsy stereotyping
ISSN号	0253-9756
文献子类	Article
英文摘要	AIM: To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors. METHODS: The receptor binding assay with calf striatum to D-1 and D-2 receptors, and the animal behavior tests were used. RESULTS: (+/-)12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D-1 and D-2 receptors were 13 and 51 nmol L(-1), respectively, in rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors. CONCLUSION: CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.
WOS关键词	ROTATIONAL BEHAVIOR ; L-STEPHOLIDINE ; TETRAHYDROPROTOBERBERINES ; RATS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
CSCD记录号	CSCD:339724
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1996TZ76400025
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274995]
专题	中国科学院上海药物研究所
通讯作者	Chen, LJ
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Chen, LJ,Xi, Y,Pang, DW,et al. Effect of (+/-)12-chloroscoulerine on brain dopamine receptors[J]. ACTA PHARMACOLOGICA SINICA,1996,17(2):185-189.
APA	Chen, LJ,Xi, Y,Pang, DW,Zhou, QT,&Jin, GZ.(1996).Effect of (+/-)12-chloroscoulerine on brain dopamine receptors.ACTA PHARMACOLOGICA SINICA,17(2),185-189.
MLA	Chen, LJ,et al."Effect of (+/-)12-chloroscoulerine on brain dopamine receptors".ACTA PHARMACOLOGICA SINICA 17.2(1996):185-189.