Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors

	Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors
	Chen, LJ; Zhang, XX; Guo, X
刊名	ACTA PHARMACOLOGICA SINICA
	1996-09
卷号	17 期号:5 页码:477-480
关键词	(+/-)12-chloroscoulerine berbines levodopa dopamine autoreceptors substantia nigra corpus striatum
ISSN号	0253-9756
文献子类	Article
英文摘要	To verify whether (+/-)12-chloroscoulerine (CSL) is antagonist or agonist effect to D-2 autoreceptors. METHODS: The levodopa content accumulated in the rat striatum was measured by HPLC-ECD, and the DA neuron firing activity in the substantia nigra zona compacta (SNC) was recorded. RESULTS: The accumulated levodopa content induced by CSL 40 mg . kg(-1) was much more than that of 1,4-butyro-lactone (BL) group (P<0.01). After ip injection of apomorphine (Ape) 5 mg . kg(-1), the levodopa content was decreased below that of BL group (P<0.05). The Apo inhibition on levodopa content was completely reversed by CSL (40 mg . kg(-1), ip) and then increased the levodopa content (2.5+/-1.1 mu g . g(-1)) over that of Apo group (0.7+/-0.3 mu g . g(-1), P<0.01). In the electrophysiologic recording, Apo (15 mu g . kg(-1), iv) induced the decrease of SNC DA cell firing rate nearly to zero. At the accumulated dose of CSL up to 80 mu g . kg(-1) (iv), the inhibition of Apo was attenuated and the firing activity was restored to predrug level. CONCLUSION: CSL showed an antagonistic action, an action to D-2 autoreceptors.
WOS关键词	L-STEPHOLIDINE ; ROTATIONAL BEHAVIOR ; RECEPTORS ; TETRAHYDROPROTOBERBERINES ; ANTAGONIST ; RATS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	中文
出版者	ACTA PHARMACOLOGICA SINICA
WOS记录号	WOS:A1996VF91900026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274961]
专题	中国科学院上海药物研究所
通讯作者	Chen, LJ
作者单位	CHINESE ACAD SCI,SHANGHAI INST MAT MED,SHANGHAI 200031,PEOPLES R CHINA.
推荐引用方式 GB/T 7714	Chen, LJ,Zhang, XX,Guo, X. Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors[J]. ACTA PHARMACOLOGICA SINICA,1996,17(5):477-480.
APA	Chen, LJ,Zhang, XX,&Guo, X.(1996).Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors.ACTA PHARMACOLOGICA SINICA,17(5),477-480.
MLA	Chen, LJ,et al."Blockade of (+/-)12-chloroscoulerine on feed-back regulation of dopamine D-2 autoreceptors".ACTA PHARMACOLOGICA SINICA 17.5(1996):477-480.