Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus

doi:10.1016/S0006-8993(97)00960-8

	Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus
	Wu, J ; Jin, GZ
刊名	BRAIN RESEARCH
	1997-11-14
卷号	775 期号:1-2 页码:214-218
关键词	tetrahydroberberine K+ current K+ channel hippocampus dissociated neuron patch clamp
ISSN号	0006-8993
DOI	10.1016/S0006-8993(97)00960-8
文献子类	Article
英文摘要	In the patch-clamp perforated whole-cell recording mode, tetrahydroberberine (THB), a novel dopamine (DA) receptor antagonist, inhibits not only DA-induced outward K+ currents, but also acetylcholine-, caffeine-or strychnine-induced outward current. However, THB does not affect either GABA-or glycine-induced Cl- currents, or non-NMDA receptor agonist-induced cation currents. As expected for a K+ channel blocker, THB evokes a downward current deflection accompanied by a decrease of conductance. It is concluded that the direct blockade of membrane K+ channels by THB underlies its inhibition of intracellular message-mediated outward currents. (C) 1997 Elsevier Science B.V.
WOS关键词	PYRAMIDAL NEURONS ; CALCIUM ; TETRAHYDROPROTOBERBERINES ; (-)-STEPHOLIDINE ; CAFFEINE ; RELEASE
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000071047300026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274880]
专题	中国科学院上海药物研究所
通讯作者	Wu, J
作者单位	1.Univ New Mexico, Sch Med, Dept Neurol, Albuquerque, NM 87131 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Wu, J,Jin, GZ. Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus[J]. BRAIN RESEARCH,1997,775(1-2):214-218.
APA	Wu, J,&Jin, GZ.(1997).Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus.BRAIN RESEARCH,775(1-2),214-218.
MLA	Wu, J,et al."Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus".BRAIN RESEARCH 775.1-2(1997):214-218.