Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB | |
Yuan, ST; Hu, XQ; Lu, JP; KeiKi, H; Zhai, WR; Zhang, YE | |
刊名 | WORLD JOURNAL OF GASTROENTEROLOGY
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2000-04 | |
卷号 | 6期号:2页码:231-233 |
ISSN号 | 1007-9327 |
文献子类 | Article |
英文摘要 | AIM To investigate the expression of integrins in rats liver during 3'-Me-DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis. METHODS The expressions of integrins alpha(1), alpha(2), alpha(3) and alpha(5) and epidermal keratin (EK) were observed by immunohistochemical PAP method. RESULTS In the normal liver tissues, hepatocytes express integrins alpha(1) and alpha(5) and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins alpha(1), alpha(2), alpha(3) and alpha(5) and in hyperplastic bile duct epithelium, integrins alpha(1), alpha(5) and EK. Expression of integrins alpha(1), alpha(2), alpha(3) and alpha(5) were obviously decreased in the preneoplastic nodules and primary carcinoma but expressions of integrins alpha(1) and alpha(5) in metastasis in the lung and diaphragma were higher than those in primary carcinoma. CONCLUSION Integrins alpha(1) and alpha(5) may play a major role in chemically induced hepatocarcinogenesis and metastasis in rats. |
WOS关键词 | CELL-ADHESION ; FIBRONECTIN ; MODULATION ; PROTEINS ; LIVER |
WOS研究方向 | Gastroenterology & Hepatology |
语种 | 英语 |
出版者 | W J G PRESS |
WOS记录号 | WOS:000086613700013 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/274632] ![]() |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Yuan, ST |
作者单位 | 1.Okayama Univ, Dept Pathol, Okayama, Japan 2.Shanghai Med Univ, Dept Pathol, Shanghai 200032, Peoples R China |
推荐引用方式 GB/T 7714 | Yuan, ST,Hu, XQ,Lu, JP,et al. Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2000,6(2):231-233. |
APA | Yuan, ST,Hu, XQ,Lu, JP,KeiKi, H,Zhai, WR,&Zhang, YE.(2000).Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB.WORLD JOURNAL OF GASTROENTEROLOGY,6(2),231-233. |
MLA | Yuan, ST,et al."Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB".WORLD JOURNAL OF GASTROENTEROLOGY 6.2(2000):231-233. |
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