Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB

	Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB
	Yuan, ST ; Hu, XQ ; Lu, JP ; KeiKi, H ; Zhai, WR ; Zhang, YE
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	2000-04
卷号	6 期号:2 页码:231-233
ISSN号	1007-9327
文献子类	Article
英文摘要	AIM To investigate the expression of integrins in rats liver during 3'-Me-DAB induced hepatocarcinogenesis and to find out the relationship between integrins and liver cancer metastasis. METHODS The expressions of integrins alpha(1), alpha(2), alpha(3) and alpha(5) and epidermal keratin (EK) were observed by immunohistochemical PAP method. RESULTS In the normal liver tissues, hepatocytes express integrins alpha(1) and alpha(5) and in the bile duct epithlium, EK. In liver cirrhosis, hepatocytes highly express integrins alpha(1), alpha(2), alpha(3) and alpha(5) and in hyperplastic bile duct epithelium, integrins alpha(1), alpha(5) and EK. Expression of integrins alpha(1), alpha(2), alpha(3) and alpha(5) were obviously decreased in the preneoplastic nodules and primary carcinoma but expressions of integrins alpha(1) and alpha(5) in metastasis in the lung and diaphragma were higher than those in primary carcinoma. CONCLUSION Integrins alpha(1) and alpha(5) may play a major role in chemically induced hepatocarcinogenesis and metastasis in rats.
WOS关键词	CELL-ADHESION ; FIBRONECTIN ; MODULATION ; PROTEINS ; LIVER
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	W J G PRESS
WOS记录号	WOS:000086613700013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/274632]
专题	中国科学院上海药物研究所
通讯作者	Yuan, ST
作者单位	1.Okayama Univ, Dept Pathol, Okayama, Japan 2.Shanghai Med Univ, Dept Pathol, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Yuan, ST,Hu, XQ,Lu, JP,et al. Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2000,6(2):231-233.
APA	Yuan, ST,Hu, XQ,Lu, JP,KeiKi, H,Zhai, WR,&Zhang, YE.(2000).Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB.WORLD JOURNAL OF GASTROENTEROLOGY,6(2),231-233.
MLA	Yuan, ST,et al."Changes of integrin expression in rat hepatocarcinogenesis induced by 3 '-Me-DAB".WORLD JOURNAL OF GASTROENTEROLOGY 6.2(2000):231-233.