The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats

doi:10.1016/j.neuropharm.2006.08.006

	The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats
	Wang, Wei ; Zhou, Yuqing ; Sun, Jie ; Pan, Luanfeng ; Kang, Lin ; Dai, Zhengze ; Yu, Rong ; Jin, Guozhang; Ma, Lan
刊名	NEUROPHARMACOLOGY
	2007-02
卷号	52 期号:2 页码:355-361
关键词	L-stepholidine opiate dopamine receptor conditioned place preference re-acquisition
ISSN号	0028-3908
DOI	10.1016/j.neuropharm.2006.08.006
文献子类	Article
英文摘要	The effect Of L-stepholidine (SPD), a novel alkaloid extract of the Chinese herb Stephania with partial dopamine D1 receptor agonistic and D2 receptor antagonistic dual actions, on morphine conditioned place preference (CPP) was studied. Daily injection of morphine (10 mg/ka, i.p.) for 6 days induced CPP in rats, and daily treatment with SPD at 10 or 20 mg/kg before morphine injection dose-dependently attenuated morphine-induced CPR On the day following acquisition of morphine CPP, a single administration of SPD at 10 or 20 mg/kg failed to block the expression of CPP. However, daily administration of SPD at 20 mg/kg for 7 days attenuated the maintenance of CPP. Morphine-induced CPP extinguished after a 21-day saline training and then a single injection of morphine (3 mg/kg, i.p.) induced re-acquisition of morphine CPP; however, pretreatment with SPD at 10 or 20 mg/kg 30 min before morphine injection dose-dependently blocked morphine (3 mg/kg, i.p.)-induced re-acquisition of morphine CPP. Furthermore, our data indicate that SPD had no effect on food-induced CPP or state-dependent learning, suggesting that the observed effect of SPD does not result from an inhibition of general learning ability. These results demonstrate that SPD can inhibit acquisition, maintenance, and re-acquisition of morphine conditioned place preference and suggest its potential for treatment of opioid addiction. (c) 2006 Elsevier Ltd. All rights reserved.
WOS关键词	COCAINE-SEEKING BEHAVIOR ; RECEPTOR ANTAGONISTS ; BRAIN REWARD ; DOPAMINE RELEASE ; D-1 ; DRUG ; (-)-STEPHOLIDINE ; HALOPERIDOL ; AGONISTS ; MECHANISMS
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000244595500012
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273345]
专题	中国科学院上海药物研究所
通讯作者	Ma, Lan
作者单位	1.Fudan Univ, Shanghai Med Coll, Pharmacol Res Ctr, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Brain Sci, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Pharmacol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Wang, Wei,Zhou, Yuqing,Sun, Jie,et al. The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats[J]. NEUROPHARMACOLOGY,2007,52(2):355-361.
APA	Wang, Wei.,Zhou, Yuqing.,Sun, Jie.,Pan, Luanfeng.,Kang, Lin.,...&Ma, Lan.(2007).The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats.NEUROPHARMACOLOGY,52(2),355-361.
MLA	Wang, Wei,et al."The effect of L-stepholidine, a novel extract of Chinese herb, on the acquisition, expression, maintenance, and re-acquisition of morphine conditioned place preference in rats".NEUROPHARMACOLOGY 52.2(2007):355-361.