Solubility of silybin in aqueous hydrochloric acid solution

doi:10.1016/j.fluid.2007.03.009

	Solubility of silybin in aqueous hydrochloric acid solution
	Bai, Tong-Chun ; Zhu, Jian-Jun ; Hu, Jie ; Zhang, Hua-Li ; Huang, Cheng-Gang
刊名	FLUID PHASE EQUILIBRIA
	2007-06-15
卷号	254 期号:1-2 页码:204-210
关键词	silybin hydrochloric acid solubility salt effect pH effect molecular hydration ionization
ISSN号	0378-3812
DOI	10.1016/j.fluid.2007.03.009
文献子类	Article
英文摘要	The solubility of silybin in aqueous hydrochloric acid solution has been measured at temperatures range from 293.15 to 313.15 K. Experimental result shows that the solubility increase with the increase of both temperature and PH value. The solubility data was analyzed by a general salt-effect rule and a hydration-ionization model. We have found that the salt-effect rule is obeyed for pH < 3 where silybin is salted out. We have also found that the salt-effect rule is broken for pH > 3 where the concentration of hydrogen ion is very low. The break down of salt-effect rule has been explained by employing a model of molecular hydration-ionization where quantum chemical calculation was performed to support this model by optimizing the geometries of silybin-water complex. Based on this model, the break down of the salt-effect rule is caused by that silybin's acidity increases with the increase of the pH value, which leads to the increase of the solubility at the higher pH regime. The predicted pKa also agrees well with the experimental result. (c) 2007 Elsevier B.V. All rights reserved.
WOS关键词	SILYMARIN ; SYSTEM ; WATER ; SALT
WOS研究方向	Thermodynamics ; Chemistry ; Engineering
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000247111000024
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273224]
专题	中国科学院上海药物研究所
通讯作者	Bai, Tong-Chun
作者单位	1.Suzhou Univ, Dept Chem & Chem Engn, Suzhou 215123, Peoples R China 2.SUNY Stony Brook, Dept Chem, Stony Brook, NY 11796 USA 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Bai, Tong-Chun,Zhu, Jian-Jun,Hu, Jie,et al. Solubility of silybin in aqueous hydrochloric acid solution[J]. FLUID PHASE EQUILIBRIA,2007,254(1-2):204-210.
APA	Bai, Tong-Chun,Zhu, Jian-Jun,Hu, Jie,Zhang, Hua-Li,&Huang, Cheng-Gang.(2007).Solubility of silybin in aqueous hydrochloric acid solution.FLUID PHASE EQUILIBRIA,254(1-2),204-210.
MLA	Bai, Tong-Chun,et al."Solubility of silybin in aqueous hydrochloric acid solution".FLUID PHASE EQUILIBRIA 254.1-2(2007):204-210.