A new synthetic method of natural product trichostatin A

	A new synthetic method of natural product trichostatin A
	Zhao Xi 2; Zhang Shi-Lei 1,2; Duan Wen-Hu1,2
刊名	CHINESE JOURNAL OF ORGANIC CHEMISTRY
	2007-12
卷号	27 期号:12 页码:1509-1515
关键词	trichostatin A histone deacetylase inhibitor L-proline synthesis
ISSN号	0253-2786
文献子类	Article
英文摘要	An efficient synthesis of trichostatin A, A potent histone deacetylase inhibitor, was reported. The key point in this new approach lied in the highly stereocontrolled establishment of its chiral center using L-proline-catalyzed aldol reaction between p-nitrobenzaldehyde and propaidehyde. The aldol product was obtained with >99% ee and high de (anti : syn =16 : 1). No racemization was found in the following process and the synthetic trichostatin A was a pure R enantiomer with more than 99% ee.
WOS关键词	HISTONE DEACETYLASE INHIBITORS ; FRIEND LEUKEMIC-CELLS ; POTENT ; DIFFERENTIATION ; ENZYME
WOS研究方向	Chemistry
语种	中文
CSCD记录号	CSCD:3047138
出版者	SCIENCE CHINA PRESS
WOS记录号	WOS:000251996300007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273101]
专题	中国科学院上海药物研究所
通讯作者	Zhao Xi
作者单位	1.E China Univ Sci & Technol, Dept Pharmaceut Sci, Sch Pharm, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Zhao Xi,Zhang Shi-Lei,Duan Wen-Hu. A new synthetic method of natural product trichostatin A[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2007,27(12):1509-1515.
APA	Zhao Xi,Zhang Shi-Lei,&Duan Wen-Hu.(2007).A new synthetic method of natural product trichostatin A.CHINESE JOURNAL OF ORGANIC CHEMISTRY,27(12),1509-1515.
MLA	Zhao Xi,et al."A new synthetic method of natural product trichostatin A".CHINESE JOURNAL OF ORGANIC CHEMISTRY 27.12(2007):1509-1515.