Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy

	Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy
	Li Ci; Zhao Liangcai; Fang Yiqun; Chen Ruiyong; Liu Yuming; Yuan Hengrong; Li Jun; Chen Haiting; Lin Donghai; Xiao Weibing
刊名	Chinese Journal of Nautical Medicine and Hyperbaric Medicine
	2014
卷号	21 期号:5 页码:289
关键词	Saturation dive Helium-oxygen Nuclear magnetic resonance Metabonomics
ISSN号	1009-6906
其他题名	利用~1H核磁共振代谢组学技术研究250m饱和暴露对人体代谢模式的影响
文献子类	Article
英文摘要	Objective To investigate the effects of 250 m helium-oxygen (heliox) saturation dive on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy. Methods Seven male divers performed the 250 m heliox saturation dive by using the dry diving simulator. Urine morning samples were collected at various stages, before dive, during dive and after dive. Urine spectra were acquired by using the 600 MHz nuclear magnetic resonance (NMR),and then mode identification was performed by SIMCA-P + 12. 0 software. Results Stay at the storage depth, decompression and the whole process of saturation exposure at a pressure of 250 m exerted significant effects on the metabolismof divers. From urine samples, 13 metabolites were screened (P<0.05). They were creatine, creatitine, glucose, citric acid, alpha-ketoglutarate, lactate, acetoacetate, acetate, phenylalanine, isoleucine, N-oxide trimethylamine, dimethylamine and hippuric acid, which could reflect energy metabolism, amino acid metabolism, amine metabolism and kidney function. Conclusions NMR-based metabonomic analysis could provide information on endogenous metabolites which characterized changes in energy supply form induced by the 250 m heliox saturation exposure in the dry chamber.
资助项目	解放军总后勤部重点科研计划项目[00000000] ; 总后卫生部面上项目[00000000] ; 海军后勤部科研计划项目[00000000]
WOS研究方向	General & Internal Medicine (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5289834
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269308]
专题	中国科学院上海药物研究所
作者单位	Naval Medical Research Institute, Shanghai 200433, China.
推荐引用方式 GB/T 7714	Li Ci,Zhao Liangcai,Fang Yiqun,et al. Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2014,21(5):289.
APA	Li Ci.,Zhao Liangcai.,Fang Yiqun.,Chen Ruiyong.,Liu Yuming.,...&Xiao Weibing.(2014).Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy.Chinese Journal of Nautical Medicine and Hyperbaric Medicine,21(5),289.
MLA	Li Ci,et al."Effects of 250 m helium-oxygen saturation exposure on the mode of human metabolism by high-resolution nuclear magnetic resonance spectroscopy".Chinese Journal of Nautical Medicine and Hyperbaric Medicine 21.5(2014):289.