Review of relationship between vascular endothelial growth factor family & receptors and tumor angiogenesis | |
Chen Shan2; Jin Wei2; Min Ping2; Lu He1 | |
刊名 | Chinese Bulletin of Life Sciences
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2004 | |
卷号 | 16期号:1页码:19-23 |
关键词 | vascular endothelial growth factor vascular endothelial growth factors receptors angiogenesis |
ISSN号 | 1004-0374 |
其他题名 | 血管内皮生长因子家族及其受体与肿瘤血管生成研究进展 |
文献子类 | Review |
英文摘要 | Vascular endothelial growth factor (VEGF) also named vascular permeability factor (VPF), is an impor-tant positive regulator for angiogenesis. This is one target of the anticancer research. Discovered members of VEGF family include: VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E and placenta growth factor (PLGF). Recep-tors of VEGF are VEGFR-l(flt-l), VEGFR-2(flk-l/KDR), VEGFR-3(flt-4) and neuropilin(NPRl/NPR2). Mem-bers of this family can selectively promote mitosis of vascular endotheial cells or lymphatic endothelial cells, stimu-late endothelial cells to proliferate and induce angiogenesis. They also enhance the permeability of microvessels, help to establish capillary vessels net. This article mainly reviewed the structures, functional characteristics, rela-tionship between VEGF and its inhibitors and tumor angiogenesis. |
WOS研究方向 | General & Internal Medicine (provided by Clarivate Analytics) |
语种 | 中文 |
CSCD记录号 | CSCD:1507915 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/268401] ![]() |
专题 | 中国科学院上海药物研究所 |
作者单位 | 1.Le pole franco-chinois du science du vivant et genomique, Ruijin Hospital, Shanghai 200025, China. 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.; |
推荐引用方式 GB/T 7714 | Chen Shan,Jin Wei,Min Ping,et al. Review of relationship between vascular endothelial growth factor family & receptors and tumor angiogenesis[J]. Chinese Bulletin of Life Sciences,2004,16(1):19-23. |
APA | Chen Shan,Jin Wei,Min Ping,&Lu He.(2004).Review of relationship between vascular endothelial growth factor family & receptors and tumor angiogenesis.Chinese Bulletin of Life Sciences,16(1),19-23. |
MLA | Chen Shan,et al."Review of relationship between vascular endothelial growth factor family & receptors and tumor angiogenesis".Chinese Bulletin of Life Sciences 16.1(2004):19-23. |
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