Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy

	Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy
	Ye Xiangyu; Sheng Yaohua; Qiu Changbin; Wang Yulan; Ding Shuangshuang
刊名	Ophthalmic Research
	2006
卷号	24 期号:2 页码:160-164
关键词	Palosuran Urotensin-Ⅱ antagonist diabetic retinopathy Palosuran pericyte basement membrane thickness
ISSN号	1003-0808
其他题名	Urotensin-Ⅱ受体拮抗剂对DR微血管病变的影响
文献子类	Article
英文摘要	Objective Urotensin-Ⅱ is a vasoactive peptide with stronger vasoconstrictive effectiveness. It may be involved in the pathogenesis of diabetic retinopathy. This paper was to assess the effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy （DR）. Methods Animal models of DR were induced by injection of streptozocin in rats. Experimental rats were randomly divided into Sham ＋ Veh （normal control, 11 rats）, DM ＋ Veh （diabetic model without treatment, 7 rats） and DM ＋ 362 （diabetic model with Urotensin-Ⅱ antagonist treatment, 20 rats） groups. Mean body weight and blood glucose levels of rats were recorded every 2 weeks during the experiment period and rats were scarified at the end of 6 months. Left eye of each rat was processed for elastase digest to determine retinal endothelial/pericyte cell ratios and the right eye were used for transmission electron microscopy examination to detect basement membrane thickness. Results Blood glucose level was significantly higher in the DM ＋ Veh group and DM ＋ 362 group than the Sham ＋ Veh group 2 weeks after diabetes was induced, and that of DM ＋ 362 group was considerably lower in comparison with DM ＋ Veh group after 4 weeks. There was no apparent difference in mean body weight between DM ＋ Veh group and DM ＋ 362 group （P 〉 0.05）. Endothelial cell/pericyte ratios and basement membrane thickness were significantly increased in the DM ＋ 362 rats compared with Sham ＋ Veh rats （1.600.01 versus 1.190.01 in E/P ratios, P 〈 0.01 and 106.4018.65 nm versus 83.3614.46 nm in basement membrane thickness, P 〈 0.01） and significantly reduced in comparison with DM ＋ Veh rats （2.100.07 in E/P ratios, P 〈 0.01 and 116.9117.65 nm in basement membrane thickness, P 〈 0.01）. Conclusion Urotensin-Ⅱ antagonist may be useful in prevention from the early pathological changes of DR.
WOS研究方向	Ophthalmology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:2337554
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/268263]
专题	中国科学院上海药物研究所
作者单位	Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University, Shanghai 200092, China.
推荐引用方式 GB/T 7714	Ye Xiangyu,Sheng Yaohua,Qiu Changbin,et al. Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy[J]. Ophthalmic Research,2006,24(2):160-164.
APA	Ye Xiangyu,Sheng Yaohua,Qiu Changbin,Wang Yulan,&Ding Shuangshuang.(2006).Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy.Ophthalmic Research,24(2),160-164.
MLA	Ye Xiangyu,et al."Effects of Urotensin-Ⅱ antagonist on microvascular pathological changes in diabetic retinopathy".Ophthalmic Research 24.2(2006):160-164.