Progress in ab initio protein structure prediction

	Progress in ab initio protein structure prediction
	Zhou Jianhong 2; Ai Guanhua 2; Fang Huisheng 2; Chen Kaixian1
刊名	China Journal of Bioinformatics
	2011
卷号	9 期号:1 页码:1-5
关键词	Rosetta Ab initio protein prediction scoring function conformational search strategy Rosetta
ISSN号	1672-5565
其他题名	蛋白质结构从头预测方法研究进展
文献子类	Article
英文摘要	Ab initio protein structure prediction is not dependent on the template, only from the amino acid sequence information. The key to this kind of protein prediction is the proper definition of energy function, accurate selection of a computer search algorithm to find the lowest energy value. Based on this, this paper describes energy functions and conformational search strategies, and lists several successful ab initio prediction methods, We conclude that the major direction of ab initio prediction in recent years is the statistical knowledge-based energy function, the existing conformational search of ab initio prediction methods all use Monte Carlo method. This shows that with the study of protein structure prediction, the critical issues such as the building of energy function, the choice of comformation search method and ab initio prediction of macromolecular proteins have made breakthrough development
WOS研究方向	Biochemistry & Molecular Biology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4168766
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267886]
专题	中国科学院上海药物研究所
作者单位	1.Drug Discovery and Design Center, Shanghai Institue of Materia Medica, Chinese Academic Science, Shanghai 201203, China. 2.School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China.;
推荐引用方式 GB/T 7714	Zhou Jianhong,Ai Guanhua,Fang Huisheng,et al. Progress in ab initio protein structure prediction[J]. China Journal of Bioinformatics,2011,9(1):1-5.
APA	Zhou Jianhong,Ai Guanhua,Fang Huisheng,&Chen Kaixian.(2011).Progress in ab initio protein structure prediction.China Journal of Bioinformatics,9(1),1-5.
MLA	Zhou Jianhong,et al."Progress in ab initio protein structure prediction".China Journal of Bioinformatics 9.1(2011):1-5.