A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.

doi:10.1039/c2ob06747a

	A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.
	Zhang, Hua 1,2; Conte, Melissa M.1; Huang, Xiao-Cong 1; Khalil, Zeinab 1; Capon, Robert J.1
刊名	Organic and Biomolecular Chemistry
	2012-04-07
卷号	10 期号:13 页码:2656-2663
ISSN号	14770520
DOI	10.1039/c2ob06747a
文献子类	Article
英文摘要	Fractionation of a southern Australian marine sponge, Ianthella sp., yielded sixteen metabolites including a new class of pyrrolidone, ianthellidones A-F (1-6), a new class of furanone, ianthellidones G-H (7-8), new and known lamellarins, lamellarins O1 (9), O2 (10), O (11) and Q (12), plus the known 4-hydroxybenzaldehyde (13), 4-hydroxybenzoic acid (14), 4-methoxybenzoic acid (15) and ethyl 4-hydroxybenzoate (16). Structures for all Ianthella metabolites were determined by detailed spectroscopic analysis, supported by a plausible biosynthetic relationship. The ianthellidones were non-cytotoxic towards two human colon cancer cell lines (SW620 and SW620 Ad300), as well as Gram +ve and Gram -ve bacteria, and a fungus. Ianthellidone F (6) and lamellarins O2 (10) and O (11) displayed modest BACE inhibitory properties (IC50> 10 μM), while lamellarin O1 (9) was more potent (IC5050> 22 μM), was an inhibitor of the multi-drug resistance efflux pump P-glycoprotein, and displayed selective growth inhibitory activity against the Gram +ve bacterium Bacillus subtilis (ATCC 6633) (IC502.5 μM).
语种	英语
出版者	Royal Society of Chemistry
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266984]
专题	中国科学院上海药物研究所
通讯作者	Capon, Robert J.
作者单位	1.Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, St. Lucia, QLD 4072, Australia; 2.Department of Natural Medicinal Chemsitry, Shanghai Insititue of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Zhang, Hua,Conte, Melissa M.,Huang, Xiao-Cong,et al. A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.[J]. Organic and Biomolecular Chemistry,2012,10(13):2656-2663.
APA	Zhang, Hua,Conte, Melissa M.,Huang, Xiao-Cong,Khalil, Zeinab,&Capon, Robert J..(2012).A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp..Organic and Biomolecular Chemistry,10(13),2656-2663.
MLA	Zhang, Hua,et al."A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.".Organic and Biomolecular Chemistry 10.13(2012):2656-2663.