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	The basement membrane and metastasis
	Zhou, Jin; Cheng, Yi; Ding, Jian
	2006-10
卷号	37
期号	4
页码	307-12
英文摘要	The basement membrane (BM) is a specialised form of extracellular matrix (ECM) , which is a major barrier to tumor cells during metastasis. The component of basement membrane plays important role in regulating tumor metastasis by interacting with cell surface receptor integrins. On the other hand, tumor cells secrete Matrix metalloproteinase and Heparanase to degrade the extracellular matrix components, as well as adjust the expression of surface receptor-integrins to facilitate migration in basement membrane and adhesion to target organs. Understanding of the cell-ECM interaction may offer us new strategy for drug discovery.
会议录	Sheng li ke xue jin zhan [Progress in physiology]
文献子类	Meeting Abstract;Article
语种	中文
内容类型	会议论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266941]
专题	中国科学院上海药物研究所
作者单位	Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Shanghai 201203, China
推荐引用方式 GB/T 7714	Zhou, Jin,Cheng, Yi,Ding, Jian. The basement membrane and metastasis[C]. 见:.

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