Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection

doi:10.1038/srep29823

	Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection
	Wei, Junying 2; Zhang, Yanqiong 2; Jia, Qiang 2; Liu, Mingwei 3; Li, Defeng 2; Zhang, Yi 2; Song, Lei 3; Hu, Yanzhen 2; Xian, Minghua 2; Yang, Hongjun 2
刊名	Scientific reports
	2016-07-19
卷号	6 页码:29823
ISSN号	2045-2322
DOI	10.1038/srep29823
文献子类	Article
英文摘要	Systematic investigations of complex pathological cascades during ischemic brain injury help to elucidate novel therapeutic targets against cerebral ischemia. Although some transcription factors (TFs) involved in cerebral ischemia, systematic surveys of their changes during ischemic brain injury have not been reported. Moreover, some multi-target agents effectively protected against ischemic stroke, but their mechanisms, especially the targets of TFs, are still unclear. Therefore, a comprehensive approach by integrating network pharmacology strategy and a new concatenated tandem array of consensus transcription factor response elements method to systematically investigate the target TFs critical in the protection against cerebral ischemia by a medication was first reported, and then applied to a multi-target drug, Danhong injection (DHI). High-throughput nature and depth of coverage, as well as high quantitative accuracy of the developed approach, make it more suitable for analyzing such multi-target agents. Results indicated that pre-B-cell leukemia transcription factor 1 and cyclic AMP-dependent transcription factor 1, along with six other TFs, are putative target TFs for DHI-mediated protection against cerebral ischemia. This study provides, for the first time, a systematic investigation of the target TFs critical to DHI-mediated protection against cerebral ischemia, as well as reveals more potential therapeutic targets for ischemic stroke.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266691]
专题	中国科学院上海药物研究所
作者单位	1.State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China 2.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; 3.State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China;
推荐引用方式 GB/T 7714	Wei, Junying,Zhang, Yanqiong,Jia, Qiang,et al. Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection[J]. Scientific reports,2016,6:29823.
APA	Wei, Junying.,Zhang, Yanqiong.,Jia, Qiang.,Liu, Mingwei.,Li, Defeng.,...&Huang, Luqi.(2016).Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection.Scientific reports,6,29823.
MLA	Wei, Junying,et al."Systematic investigation of transcription factors critical in the protection against cerebral ischemia by Danhong injection".Scientific reports 6(2016):29823.