Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora

doi:10.1016/j.fitote.2015.11.011

	Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora
	Shi, Yan-Hong3 ; Zhu, Shu 3; Ge, Yue-Wei 3; He, Yu-Min 3; Kazuma, Kohei 4; Wang, Zhengtao 2; Yoshimatsu, Kayo 1; Komatsu, Katsuko 3
刊名	Fitoterapia
	2016-01
卷号	108 页码:55-61
ISSN号	1873-6971
DOI	10.1016/j.fitote.2015.11.011
文献子类	Article
英文摘要	The methanolic extract and its subfractions from red peony root, the dried roots of Paeonia lactiflora Pallas showed potent antiallergic effects, as inhibition of immunoglobulin E (IgE)-mediated degranulation in rat basophil leukemia (RBL)-2H3 cells. Bioassay-guided fractionation led to the isolation of 16 monoterpene derivatives, including 3 new compounds, paeoniflorol (1), 4'-hydroxypaeoniflorigenone (2) and 4-epi-albiflorin (3), together with 13 known ones (4-16). The chemical structures of the new compounds were elucidated on the basis of spectroscopic and chemical evidences. Among the isolated monoterpene derivatives, nine compounds showed potent anti-allergic effects and compound 1 was the most effective. A primary structure-activity relationship of monoterpene derivatives was discussed.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266627]
专题	中国科学院上海药物研究所
通讯作者	Zhu, Shu; Komatsu, Katsuko
作者单位	1.Research Center for Medicinal Plant Resources, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki 305-0843, Japan 2.The MOE Key laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201-203, China; 3.Division of Pharmacognosy, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan; 4.Division of Kampo-Pharmaceutics, Department of Medicinal Resources, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan;
推荐引用方式 GB/T 7714	Shi, Yan-Hong,Zhu, Shu,Ge, Yue-Wei,et al. Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora[J]. Fitoterapia,2016,108:55-61.
APA	Shi, Yan-Hong.,Zhu, Shu.,Ge, Yue-Wei.,He, Yu-Min.,Kazuma, Kohei.,...&Komatsu, Katsuko.(2016).Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.Fitoterapia,108,55-61.
MLA	Shi, Yan-Hong,et al."Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora".Fitoterapia 108(2016):55-61.