Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues

doi:10.1016/S1875-5364(16)30042-5

	Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues
	Chen, Ying-Ying 2,3; Yan, Yan 2; Zhao, Zheng 1; Shi, Mei-Jing 2; Zhang, Yu-Bin 2
刊名	Chinese journal of natural medicines
	2016-06
卷号	14 期号:6 页码:449-56
ISSN号	1875-5364
DOI	10.1016/S1875-5364(16)30042-5
文献子类	Article
英文摘要	The inducible co-activator PGC-1α plays a crucial role in adaptive thermogenesis and increases energy expenditure in brown adipose tissue (BAT). Meanwhile, chronic inflammation caused by infiltrated-macrophage in the white adipose tissue (WAT) is a target for the treatment of obesity. Bofutsushosan (BF), a traditional Chinese medicine composed of 17 crude drugs, has been widely used to treat obesity in China, Japan, and other Asia countries. However, the mechanism underlying anti-obesity remains to be elucidated. In the present study, we demonstrated that BF oral administration reduced the body weight of obese mice induced by high-fat diet (HFD) and alleviated the level of biochemical markers (P < 0.05), including blood glucose (Glu), total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-C) and insulin. Our further results also indicated that oral BF administration increased the expression of PGC-1α and UCP1 in BAT. Moreover, BF also reduced the expression of inflammatory cytokines in WAT, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). These findings suggested that the mechanism of BF against obesity was at least partially through increasing gene expression of PGC-1α and UCP1 for energy consumption in BAT and inhibiting inflammation in WAT.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266615]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Yu-Bin
作者单位	1.Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing 210009, China 2.State Key Laboratory of Natural Medicines, Department of Biochemistry, China Pharmaceutical University, Nanjing 210009, China; 3.Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
推荐引用方式 GB/T 7714	Chen, Ying-Ying,Yan, Yan,Zhao, Zheng,et al. Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues[J]. Chinese journal of natural medicines,2016,14(6):449-56.
APA	Chen, Ying-Ying,Yan, Yan,Zhao, Zheng,Shi, Mei-Jing,&Zhang, Yu-Bin.(2016).Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues.Chinese journal of natural medicines,14(6),449-56.
MLA	Chen, Ying-Ying,et al."Bofutsushosan ameliorates obesity in mice through modulating PGC-1α expression in brown adipose tissues and inhibiting inflammation in white adipose tissues".Chinese journal of natural medicines 14.6(2016):449-56.