Polyketides from the fungus Penicillium decumbens

doi:10.1080/10286020.2018.1424139

	Polyketides from the fungus Penicillium decumbens
	Lin, Sheng 1; Wu, Yu-Zhuo 2; Chen, Ke-Yv 1; Ye, Ji 1; Yang, Xian-Wen 1; Zhang, Wei-Dong 1
刊名	Journal of Asian natural products research
	2018-05
卷号	20 期号:5 页码:445-450
ISSN号	1477-2213
DOI	10.1080/10286020.2018.1424139
文献子类	Article
英文摘要	Two new polyketides, 3,11-dihydroxy-6,8-dimethyldodecanoic acid (1) and trichopyrone B (2), together with two known polyketides, sorbicillin (3) and penicillone A (4), have been isolated from the cultures broth of the fungus Penicillium decumbens. Their structures were elucidated by extensive spectroscopic analysis. All isolated compounds were evaluated for their antibacterial and cytotoxic activities. Of these, compound 3 showed antifungal activity toward Candida albicans Y0109 with a MIC value of 50 μM. Moreover, compounds 3 and 4 exhibited selective cytotoxicity against the human hepatocellular carcinoma (QGY-7703) cell line with the IC values of 32.5 and 22.8 μM, respectively.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266591]
专题	中国科学院上海药物研究所
作者单位	1.a Department of Natural Product Chemistry, School of Pharmacy , Second Military Medical University , Shanghai 200433 , China; 2.b State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China
推荐引用方式 GB/T 7714	Lin, Sheng,Wu, Yu-Zhuo,Chen, Ke-Yv,et al. Polyketides from the fungus Penicillium decumbens[J]. Journal of Asian natural products research,2018,20(5):445-450.
APA	Lin, Sheng,Wu, Yu-Zhuo,Chen, Ke-Yv,Ye, Ji,Yang, Xian-Wen,&Zhang, Wei-Dong.(2018).Polyketides from the fungus Penicillium decumbens.Journal of Asian natural products research,20(5),445-450.
MLA	Lin, Sheng,et al."Polyketides from the fungus Penicillium decumbens".Journal of Asian natural products research 20.5(2018):445-450.