Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources

doi:10.1002/ptr.5216

	Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources
	Jiao, Ying 1,2; Chen, Pei-Hua ; Xiong, Ai-Zhen ; Wang, Zheng-Tao ; Tsim, Karl Wah-Keung ; Chou, Gui-Xin ; Xu, Hong
刊名	Phytotherapy research : PTR
	2015-01
卷号	29 期号:1 页码:22-9
ISSN号	1099-1573
DOI	10.1002/ptr.5216
文献子类	Article
英文摘要	Different members of Lagochilus genus have been used in folkloric medicine to treat hemorrhages and inflammation. However, only a few species of them have received scientific attention supporting their efficacy. Here, the hemostatic and antiinflammatory activities of five Lagochilus species were determined and compared by using in vivo assays. The results showed that the extracts of Lagochilus lanatonodus and Lagochilus diacanthophyllus showed better hemostatic activities among five species. The high doses of L. lanatonodus extracts were able to shorten the values of thrombin time, activated partial thromboplastin time and prothrombin time in a rat model. Moreover, the extracts of L. lanatonodus and L. diacanthophyllus showed strong inhibitory effects on the acute phase of inflammation in both xylene-induced ear edema mouse model and carrageenan-induced paw edema rat model. In parallel, the treatment of these extracts modulated the expressions of those inflammatory parameters, that is, nitric oxide, prostaglandin E2 , inducible nitric oxide synthase, malondialdehyde and superoxide dismutase. L. lanatonodus and L. diacanthophyllus showed better hemostatic and antiinflammatory activities in several test models: these results therefore supported the folkloric utilization. L. lanatonodus was found to be the most active Lagochilus species.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266476]
专题	中国科学院上海药物研究所
作者单位	1.Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, 201203, China 2.The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China;
推荐引用方式 GB/T 7714	Jiao, Ying,Chen, Pei-Hua,Xiong, Ai-Zhen,et al. Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources[J]. Phytotherapy research : PTR,2015,29(1):22-9.
APA	Jiao, Ying.,Chen, Pei-Hua.,Xiong, Ai-Zhen.,Wang, Zheng-Tao.,Tsim, Karl Wah-Keung.,...&Xu, Hong.(2015).Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources.Phytotherapy research : PTR,29(1),22-9.
MLA	Jiao, Ying,et al."Evaluation of hemostatic and anti-inflammatory activities of extracts from different Lagochilus species in experimental animals: comparison of different extractives and sources".Phytotherapy research : PTR 29.1(2015):22-9.