The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis | |
Ren, Gaiyan1,3; Sun, Aning1,3; Deng, Chao1,3; Zhang, Jingjing1,3; Wu, Xiaojun1,3; Wei, Xiaohui1,3; Mani, Sridhar4; Dou, Wei2,3; Wang, Zhengtao1,3 | |
刊名 | American journal of physiology. Gastrointestinal and liver physiology
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2015-10-01 | |
卷号 | 309期号:7页码:G517-27 |
ISSN号 | 1522-1547 |
DOI | 10.1152/ajpgi.00133.2015 |
文献子类 | Article |
英文摘要 | Cardamonin is a naturally occurring chalcone with strong anti-inflammatory activity. However, the direct effect of cardamonin on intestinal inflammation remains elusive. In the present study, we found that cardamonin markedly ameliorated dextran sulfate sodium-induced mouse body weight loss, diarrhea, colon shortening, spleen swelling, and histological damage, which correlated with a decline in the activity of myeloperoxidase and the production of nitric oxide, tumor necrosis factor-α and interleukin-6 in the colon. The upregulation of toll-like receptor 4 after dextran sulfate sodium treatment was associated with an increase in the activation of myeloid differentiation factor 88, interleukin-1 receptor-associated kinase-1, nuclear factor-κB (NF-κB) p65, inhibitor κBα, and inhibitor κB kinase-α/β, as well as the mitogen-activated protein kinase molecules of extracellular signal-regulated kinase and c-Jun NH2-terminal kinase, and this upregulation was reversed by cardamonin administration. Moreover, cardamonin blocked the nuclear translocation of NF-κB p65, inhibited NF-κB-luciferase activity, and downregulated NF-κB target genes expression. The present study clearly demonstrates a beneficial effect of cardamonin on experimental inflammatory bowel disease via a mechanism associated with suppression of toll-like receptor 4 expression and inactivation of NF-κB and mitogen-activated protein kinase pathways. This study may give insight into the further evaluation of the therapeutic potential of cardamonin or its derivatives for human inflammatory bowel disease. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/266474] ![]() |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Dou, Wei |
作者单位 | 1.and; 2.and vivi 3.Shanghai Key Laboratory of Complex Prescription and MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China; 4.Department of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York; |
推荐引用方式 GB/T 7714 | Ren, Gaiyan,Sun, Aning,Deng, Chao,et al. The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis[J]. American journal of physiology. Gastrointestinal and liver physiology,2015,309(7):G517-27. |
APA | Ren, Gaiyan.,Sun, Aning.,Deng, Chao.,Zhang, Jingjing.,Wu, Xiaojun.,...&Wang, Zhengtao.(2015).The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis.American journal of physiology. Gastrointestinal and liver physiology,309(7),G517-27. |
MLA | Ren, Gaiyan,et al."The anti-inflammatory effect and potential mechanism of cardamonin in DSS-induced colitis".American journal of physiology. Gastrointestinal and liver physiology 309.7(2015):G517-27. |
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