Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment

doi:10.1016/j.carbpol.2018.04.100

	Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment
	Pang, Guibin 3,4; Wang, Fujun 1,3,4; Zhang, Leshuai W 2,5
刊名	Carbohydrate polymers
	2018-09-01
卷号	195 页码:243-256
ISSN号	1879-1344
DOI	10.1016/j.carbpol.2018.04.100
文献子类	Article;Review
英文摘要	Polysaccharides from natural resources possess anti-tumor activities for decades, but the efficacy of polysaccharides as the adjuvant drugs for cancer treatment at prescribed doses remains open for debate. In this review, molecular mechanisms involved in direct killing effects of polysaccharides, including apoptosis, cell cycle arrest and mitochondria/DNA damage were described. However, the concentrations/doses used to reach the direct killing effects are too high to be applicable. Polysaccharides can also exert anti-tumor effects through immunoregulation at lower doses, and the effects of polysaccharides on natural killer cells, dendritic cells and other lymphocytes for tumor destruction, along with the receptor recognition and downstream signaling pathways, were delineated. Unfortunately, the prescribed doses of polysaccharides are too low to stimulate immunoresponse, resulting in the failure of some clinical trials. Therefore, understanding the sophisticated mechanisms of the immunoregulatory function of natural polysaccharides with refined doses for clinical use will help the standardization of traditional medicine.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266467]
专题	中国科学院上海药物研究所
通讯作者	Wang, Fujun; Zhang, Leshuai W
作者单位	1.Zhejiang Reachall Pharmaceutical Co. Ltd., Zhejiang, 322100, China; 2.Zhejiang Reachall Pharmaceutical Co. Ltd., Zhejiang, 322100, China 3.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China; 4.Shanghai R&D Centre for Standardization of Chinese Medicines, Shanghai, 201210, China; 5.School for Radiological and Interdisciplinary Sciences (RAD-X), State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, 215123, China;
推荐引用方式 GB/T 7714	Pang, Guibin,Wang, Fujun,Zhang, Leshuai W. Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment[J]. Carbohydrate polymers,2018,195:243-256.
APA	Pang, Guibin,Wang, Fujun,&Zhang, Leshuai W.(2018).Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment.Carbohydrate polymers,195,243-256.
MLA	Pang, Guibin,et al."Dose matters: Direct killing or immunoregulatory effects of natural polysaccharides in cancer treatment".Carbohydrate polymers 195(2018):243-256.