Sulfated beta-glucan derived from oat bran with potent anti-HIV activity

doi:10.1021/jf072888h

	Sulfated beta-glucan derived from oat bran with potent anti-HIV activity
	Wang, Shun Chun; Bligh, S W Annie; Zhu, Chang Lian; Shi, Song Shan; Wang, Zheng Tao; Hu, Zhi Bi; Crowder, John; Branford-White, Christopher; Vella, Cherelyn
刊名	Journal of agricultural and food chemistry
	2008-04-23
卷号	56 期号:8 页码:2624-9
ISSN号	0021-8561
DOI	10.1021/jf072888h
文献子类	Article
英文摘要	China is a major producer of oats; the annual harvested area of 350,000 ha yields approximately 465,000 tons, giving an average yield of 1.33 tons/ha. The bran is not used for animal feed as it is of poor digestibility and low nutritive content and is considered a waste byproduct. Therefore, it is advantageous to produce a value-added product from the bran. We extracted the native polysaccharide, a linear (1-3)-, (1-4)-linked beta-glucan (OBG) from the oat bran and synthesized a sulfated derivative OBGS containing 36.5% sulfate. OBGS had potent activity against a primary isolate of human immunodeficiency virus (HIV-1) in peripheral blood mononuclear cells at a concentration (EC(50)=5.98 x 10(-4) microM) approximately 15,000 times below its cytotoxic concentration. OBGS was also active postinfection (EC(50)=5.3 x 10(-4) microM) and protected pretreated peripheral mononuclear cells (EC(50)=5.2 x 10(-2) microM) washed free of the compounds prior to infection. Thus, OBGS has potential as a vaginal microbicide and is the first such report for oat bran derived sulfated beta-glucan.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266430]
专题	中国科学院上海药物研究所
作者单位	Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai Lun Road, Zhangjiang Hi-Tech Park, Shanghai 201210, People's Republic of China
推荐引用方式 GB/T 7714	Wang, Shun Chun,Bligh, S W Annie,Zhu, Chang Lian,et al. Sulfated beta-glucan derived from oat bran with potent anti-HIV activity[J]. Journal of agricultural and food chemistry,2008,56(8):2624-9.
APA	Wang, Shun Chun.,Bligh, S W Annie.,Zhu, Chang Lian.,Shi, Song Shan.,Wang, Zheng Tao.,...&Vella, Cherelyn.(2008).Sulfated beta-glucan derived from oat bran with potent anti-HIV activity.Journal of agricultural and food chemistry,56(8),2624-9.
MLA	Wang, Shun Chun,et al."Sulfated beta-glucan derived from oat bran with potent anti-HIV activity".Journal of agricultural and food chemistry 56.8(2008):2624-9.