Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice

doi:10.1016/j.jnutbio.2014.02.010

	Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice
	Fan, Shengjie 2; Zhang, Yu 2; Sun, Qinhu 1; Yu, Lijing 2; Li, Mingxia 2; Zheng, Bin 2; Wu, Ximin 2; Yang, Baican 2; Li, Yiming 2; Huang, Cheng 2
刊名	The Journal of nutritional biochemistry
	2014-07
卷号	25 期号:7 页码:702-9
ISSN号	1873-4847
DOI	10.1016/j.jnutbio.2014.02.010
文献子类	Article
英文摘要	Okra is an important tropical vegetable and source of dietary medicine. Here, we assayed the effects of an ethanol extract of okra (EO) and its major flavonoids isoquercitrin and quercetin 3-O-gentiobioside on metabolic disorders in high-fat diet-induced obese mouse. We found that treatment with EO, isoquercitrin and quercetin 3-O-gentiobioside reduced blood glucose and serum insulin levels and improved glucose tolerance in obese mice. Meanwhile, serum triglyceride levels and liver morphology in the mice were significantly ameliorated by EO and isoquercitrin treatment. Total cholesterol levels in isoquercitrin and quercetin 3-O-gentiobioside treated mice were also reduced. We also found that EO inhibited the expression of nuclear receptor transcription factor PPARγ, which is an important regulator of lipid and glucose homeostasis. Furthermore, we determined that EO and quercetin 3-O-gentiobioside have antioxidant activity in vitro. Our results indicate that okra may serve as a dietary therapy for hyperglycemia and hypertriglyceridemia.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266387]
专题	中国科学院上海药物研究所
通讯作者	Huang, Cheng
作者单位	1.Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 2.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
推荐引用方式 GB/T 7714	Fan, Shengjie,Zhang, Yu,Sun, Qinhu,et al. Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice[J]. The Journal of nutritional biochemistry,2014,25(7):702-9.
APA	Fan, Shengjie.,Zhang, Yu.,Sun, Qinhu.,Yu, Lijing.,Li, Mingxia.,...&Huang, Cheng.(2014).Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice.The Journal of nutritional biochemistry,25(7),702-9.
MLA	Fan, Shengjie,et al."Extract of okra lowers blood glucose and serum lipids in high-fat diet-induced obese C57BL/6 mice".The Journal of nutritional biochemistry 25.7(2014):702-9.