Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway

doi:10.1371/journal.pone.0135893

	Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway
	Sun, Qinhu 1,2; Chou, Guixin 1,2
刊名	PloS one
	2015
卷号	10 期号:8 页码:e0135893
ISSN号	1932-6203
DOI	10.1371/journal.pone.0135893
文献子类	Article
英文摘要	Two 2″-isopropenyl dihydrofuran isoflavonoids (1 and 3), one 2″-isopropenyl dihydrofuran chromone (2), as well as 13 known compounds were isolated from the herbs of Crotalaria albida. Their structures and relative configurations were elucidated via NMR and HRESIMS analyses. The 2″ S absolute configuration of 1 and 2 were deduced by comparing their NOESY spectra with that of 3, which was determined via single crystal X-ray diffraction (CuKα). The 3R absolute configuration of 1 was determined by CD. Compounds 1, 2, and 3 inhibit the adipocyte differentiation and lipid accumulation of 3T3-L1 through down-regulation of PPAR-γ activity.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266362]
专题	中国科学院上海药物研究所
作者单位	1.Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China 2.The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica of Shanghai University of Traditional Chinese Medicine, Shanghai, China;
推荐引用方式 GB/T 7714	Sun, Qinhu,Chou, Guixin. Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway[J]. PloS one,2015,10(8):e0135893.
APA	Sun, Qinhu,&Chou, Guixin.(2015).Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway.PloS one,10(8),e0135893.
MLA	Sun, Qinhu,et al."Isoflavonoids from Crotalaria albida Inhibit Adipocyte Differentiation and Lipid Accumulation in 3T3-L1 Cells via Suppression of PPAR-γ Pathway".PloS one 10.8(2015):e0135893.