Abietane diterpenoids from Caryopteris incana (Thunb.) Miq

doi:10.1039/c6ob00139d

	Abietane diterpenoids from Caryopteris incana (Thunb.) Miq
	Zhao, Sen-Miao; Chou, Gui-Xin; Yang, Qing-Shan; Wang, Wei; Zhou, Jian-Li
刊名	Organic & biomolecular chemistry
	2016-04-14
卷号	14 期号:14 页码:3510-20
ISSN号	1477-0539
DOI	10.1039/c6ob00139d
文献子类	Article
英文摘要	Twelve new diterpenes, caryopincaolide A-L (1-4, 11-12, 16-19, 27-28), together with twenty-eight known diterpenes, have been isolated from the whole plant of Caryopteris incana (Thunb.) Miq. Their structures were elucidated on the basis of 1D and 2D NMR, IR, X-ray crystal diffraction and mass spectroscopic data, as well as ECD calculations. All compounds were tested for in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory activity, with compounds 3, 4, 28, 29, and 40 exhibiting DPP-IV inhibitory effects with IC50 values ranging from 54.2 to 228.9 μM. Compounds 1, 3 and 4 also showed potent activity toward the inhibition of the growth of human cancer cells and 1 can induce apoptosis in Hey and A-549 cells.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266355]
专题	中国科学院上海药物研究所
通讯作者	Zhao, Sen-Miao
作者单位	Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
推荐引用方式 GB/T 7714	Zhao, Sen-Miao,Chou, Gui-Xin,Yang, Qing-Shan,et al. Abietane diterpenoids from Caryopteris incana (Thunb.) Miq[J]. Organic & biomolecular chemistry,2016,14(14):3510-20.
APA	Zhao, Sen-Miao,Chou, Gui-Xin,Yang, Qing-Shan,Wang, Wei,&Zhou, Jian-Li.(2016).Abietane diterpenoids from Caryopteris incana (Thunb.) Miq.Organic & biomolecular chemistry,14(14),3510-20.
MLA	Zhao, Sen-Miao,et al."Abietane diterpenoids from Caryopteris incana (Thunb.) Miq".Organic & biomolecular chemistry 14.14(2016):3510-20.