A powerful test for ordinal trait genetic association analysis

doi:10.1515/sagmb-2017-0066

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	A powerful test for ordinal trait genetic association analysis
	Xue, Yuan 2,3; Wang, Jinjuan 4; Ding, Juan 1; Zhang, Sanguo 2,3; Li, Qizhai4
刊名	STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY
	2019-04-01
卷号	18 期号:2 页码:9
关键词	ordinal response power proportional odds model response selective sampling
ISSN号	2194-6302
DOI	10.1515/sagmb-2017-0066
英文摘要	Response selective sampling design is commonly adopted in genetic epidemiologic study because it can substantially reduce time cost and increase power of identifying deleterious genetic variants predispose to human complex disease comparing with prospective design. The proportional odds model (POM) can be used to fit data obtained by this design. Unlike the logistic regression model, the estimated genetic effect based on POM by taking data as being enrolled prospectively is inconsistent. So the power of resulted Wald test is not satisfactory. The modified POM is suitable to fit this type of data, however, the corresponding Wald test is not optimal when the genetic effect is small. Here, we propose a new association test to handle this issue. Simulation studies show that the proposed test can control the type I error rate correctly and is more powerful than two existing methods. Finally, we applied three tests to Anticyclic Citrullinated Protein Antibody data from Genetic Workshop 16.
资助项目	Beijing Natural Science Foundation[Z180006] ; National Science Foundation of China[11722113] ; National Science Foundation of China[11501134]
WOS研究方向	Biochemistry & Molecular Biology ; Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	WALTER DE GRUYTER GMBH
WOS记录号	WOS:000463667100002
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/34458]
专题	系统科学研究所
通讯作者	Li, Qizhai
作者单位	1.Guangxi Normal Univ, Sch Math & Stat, Guilin, Peoples R China 2.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Key Lab Big Data Min & Knowledge Management, Beijing, Peoples R China 4.Chinese Acad Sci, Acad Math & Syst Sci, LSC, NCMIS, Zhongguancun East Rd 55, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xue, Yuan,Wang, Jinjuan,Ding, Juan,et al. A powerful test for ordinal trait genetic association analysis[J]. STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY,2019,18(2):9.
APA	Xue, Yuan,Wang, Jinjuan,Ding, Juan,Zhang, Sanguo,&Li, Qizhai.(2019).A powerful test for ordinal trait genetic association analysis.STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY,18(2),9.
MLA	Xue, Yuan,et al."A powerful test for ordinal trait genetic association analysis".STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY 18.2(2019):9.