A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing

doi:10.1038/s41427-019-0168-0

	A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing
	Gao, Long; Zhou, Yanling; Peng, Jinliang; Xu, Chen; Xu, Qing; Xing, Min; Chang, Jiang
刊名	NPG ASIA MATERIALS
	2019-11-15
卷号	11
ISSN号	1884-4049
DOI	10.1038/s41427-019-0168-0
文献子类	Article
英文摘要	Dual adhesiveness to tissue and implant biomaterials and bioactivity to stimulate tissue regeneration are interesting properties for developing new generations of tissue-repairing hydrogels with potential new clinical applications. In this study, we developed a unique bioglass (BG)/oxidized sodium alginate (OSA) composite hydrogel with adipic acid dihydrazide (ADH)-modified y-polyglutamic acid (y-PGA) as the cross-linking agent, in which the BG plays a multifunctional role to endow the hydrogel with both dual-adhesive and bioactive properties. On one hand, the BG could improve the tissue-bonding strength by providing an alkaline microenvironment to stimulate the bond formation between OSA and the amino groups on the surrounding tissues. On the other hand, BG endows the hydrogel with adhesiveness to implantable materials by releasing Ca ions, which might chelate with the carboxyl groups of the hydrogel matrix. In addition, the composite hydrogel showed excellent bioactivity to promote vascularization and accelerate tissue regeneration. This study demonstrates that a multifunctional hydrogel can be designed by utilizing the multifunctional ions released from silicate BG, and the BG/OSA hydrogel shows good potential as an adhesive and bioactive material for wound-healing applications.
WOS关键词	POLY(L-GLUTAMIC ACID) ; INJECTABLE HYDROGELS ; CROSS-LINKING ; TISSUE ; ANTIBACTERIAL ; HEMOSTASIS ; CHEMISTRY ; MEDICINE ; ALGINATE ; CELLS
WOS研究方向	Materials Science
语种	英语
出版者	NATURE PUBLISHING GROUP
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27489]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Gao, Long,Zhou, Yanling,Peng, Jinliang,et al. A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing[J]. NPG ASIA MATERIALS,2019,11.
APA	Gao, Long.,Zhou, Yanling.,Peng, Jinliang.,Xu, Chen.,Xu, Qing.,...&Chang, Jiang.(2019).A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing.NPG ASIA MATERIALS,11.
MLA	Gao, Long,et al."A novel dual-adhesive and bioactive hydrogel activated by bioglass for wound healing".NPG ASIA MATERIALS 11(2019).