An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field

doi:10.1002/adfm.201803832

	An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field
	Shen, Aijun; Meng, Xianfu; Gao, Xiaolong; Xu, Xiaowen; Shoo, Chulun; Tang, Zhongmin; Liu, Yanyan; Bu, Wenbo; Wang, Peijun
刊名	ADVANCED FUNCTIONAL MATERIALS
	2019
卷号	29 期号:2
关键词	acidic tumor microenvironment NaGdF4@PDA@PEG nanoprobes self-aggregates SWI T1WI
ISSN号	1616-301X
DOI	10.1002/adfm.201803832
文献子类	Article
英文摘要	It is well known that acidic tumor microenvironment (TME) is very important for tumor' growth, metastasis, and drug resistance. In addition, accurate diagnosis of the solid tumors' acidic microenviroment based on the precise location of their site is especially essential for the further treatment and prognostic evaluation of cancer. Although magnetic resonance imaging (MRI) is widely used for clinical cancer diagnosis, there are still enormous challenges left for developing MRI agents which integrate anatomic imaging for tumor site location with functional imaging for pH evaluation, especially for medium or high magnetic field machines. Herein, an innovative strategy is proposed to incorporate anatomic imaging (T-1-weighted imaging, T1WI) with functional imaging (susceptibility weighted imaging, SWI) using one 3.0 T MRI scanner on an adaptable nanoplatform namely, NaGdF4@polydopamine@polyethylene glycol (PEG), which can self-aggregate under the specific low pH in TME to realize regulatory susceptibility. Moreover, the nanoplatform performs well in tumor accurately location as well as pH sensitively perception. Most importantly, the strategy not only fuses two MRI models on one nanoplatform using one 3.0 T machine to extend the application range but also provides a new insight for the design of other novel imaging agents.
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27430]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Shen, Aijun,Meng, Xianfu,Gao, Xiaolong,et al. An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field[J]. ADVANCED FUNCTIONAL MATERIALS,2019,29(2).
APA	Shen, Aijun.,Meng, Xianfu.,Gao, Xiaolong.,Xu, Xiaowen.,Shoo, Chulun.,...&Wang, Peijun.(2019).An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field.ADVANCED FUNCTIONAL MATERIALS,29(2).
MLA	Shen, Aijun,et al."An Adaptable Nanoplatform for Integrating Anatomic and Functional Magnetic Resonance Imaging under a 3.0 T Magnetic Field".ADVANCED FUNCTIONAL MATERIALS 29.2(2019).