Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy

doi:10.1039/c8mh01176a

	Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy
	Zhao, Peiran; Tang, Zhongmin; Chen, Xiaoyan; He, Ziyu; He, Xinhong; Zhang, Meng; Liu, Yanyan; Ren, Dongdong; Zhao, Kuaile; Bu, Wenbo
刊名	MATERIALS HORIZONS
	2019-02-01
卷号	6 期号:2 页码:369
ISSN号	2051-6347
DOI	10.1039/c8mh01176a
文献子类	Article
英文摘要	The key bottleneck problem of chemodynamic therapy (CDT) is that the efficiency depends heavily on an acidic chemical environment. However, there is a sufficient blood supply on the surface of solid tumours, resulting in neutral-pH surface regions, strongly reducing the effectiveness of CDT. In this study, chelating complex ferrous-cysteine-phosphotungstate nanoparticles (FcPWNPs) are synthesized to serve as new CDT nanoagents that break through the limitation of a neutral pH, ensuring CDT efficiencies at both an acidic and neutral pH. The CDT efficiency is increased by introducing cysteine and phosphotungstate, which form an Fe chelating complex to inhibit the formation of inert Fe(OH)(x), and accelerate electron transfer between ferric and ferrous ions, respectively. Due to this ferrous chelating strategy and associated electron transfer property, the FcPWNPs can destroy cancer cells from the neutral-pH tumour surface to the acidic interior, thus realizing a complete CDT cancer therapy.
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27359]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhao, Peiran,Tang, Zhongmin,Chen, Xiaoyan,et al. Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy[J]. MATERIALS HORIZONS,2019,6(2):369.
APA	Zhao, Peiran.,Tang, Zhongmin.,Chen, Xiaoyan.,He, Ziyu.,He, Xinhong.,...&Bu, Wenbo.(2019).Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy.MATERIALS HORIZONS,6(2),369.
MLA	Zhao, Peiran,et al."Ferrous-cysteine-phosphotungstate nanoagent with neutral pH fenton reaction activity for enhanced cancer chemodynamic therapy".MATERIALS HORIZONS 6.2(2019):369.