Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants

doi:10.1021/acsami.8b21558

	Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants
	Wang, Hui; Lin, Chucheng; Zhang, Xinran; Lin, Kaili; Wang, Xudong; Shen, Steve Guofang
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-02-20
卷号	11 期号:7 页码:7615
关键词	polydopamine coating osteogenic differentiation osseointegration cell signaling pathway
ISSN号	1944-8244
DOI	10.1021/acsami.8b21558
文献子类	Article
英文摘要	Surface modifications play an important role in endowing implant surface with excellent biocompatibility and bioactivity. Among the bioinspired surface modifications, the mussel-inspired polydopamine (PDA) has aroused great interest of researchers. Herein, we fabricated PDA on diverse implant surfaces, including biopolymer, biometal, and bioceramic. Then the effects of PDA coating on cell responsive behaviors in vitro and bone formation capacity in vivo were evaluated in detail. The results showed that PDA coating was fabricated on diverse samples surface successfully, which could significantly improve the hydrophilicity of different material surfaces. Furthermore, the results indicated that PDA coating exerted direct enhancing on the adhesion, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells (BMSCs) through FAK and p38 signaling pathways. During the process, the focal adhesion protein expression and osteogenic-related genes expression level (e.g., ALP, BMP2, BSP, and OPN) were considerably upregulated. Most importantly, the in vivo study confirmed that PDA coating remarkably accelerated new bone formation and enhanced osseointegration performance. Our study uncovered the biological responses stimulated by PDA coating to make a better understanding of cell/tissue-PDA interactions and affirmed that PDA, a bioinspired polymer, has great potential as a candidate and functional bioactive coating medium in bone regeneration and orthopedic application.
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27324]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Wang, Hui,Lin, Chucheng,Zhang, Xinran,et al. Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(7):7615.
APA	Wang, Hui,Lin, Chucheng,Zhang, Xinran,Lin, Kaili,Wang, Xudong,&Shen, Steve Guofang.(2019).Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants.ACS APPLIED MATERIALS & INTERFACES,11(7),7615.
MLA	Wang, Hui,et al."Mussel-Inspired Polydopamine Coating: A General Strategy To Enhance Osteogenic Differentiation and Osseointegration for Diverse Implants".ACS APPLIED MATERIALS & INTERFACES 11.7(2019):7615.