Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions

doi:10.1039/c8tb02425a

	Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions
	Ao, Haiyong; Yang, Shengbing; Nie, Bin'en; Fan, Qiming; Zhang, Quanchao; Zong, Jiajia; Guo, Shengrong; Zheng, Xuebin; Tang, Tingting
刊名	JOURNAL OF MATERIALS CHEMISTRY B
	2019-03-21
卷号	7 期号:11 页码:1951
ISSN号	2050-750X
DOI	10.1039/c8tb02425a
文献子类	Article
英文摘要	Implant infection is one of the most severe complications after orthopedic surgery. The construction of an antibacterial coating on orthopedic implants with release-killing or contact-killing is one of the most efficient strategies to prevent implant-related infections. Here we reported a hydroxypropyltrimethyl ammonium chloride chitosan (HACC) based multilayer modified plasma-sprayed porous titanium coating generated via the layer-by-layer covalent-immobilized method. We demonstrated that the multilayer coating inhibited the colonization and biofilm formation of several bacterial strains, including Staphylococcus aureus (ATCC 25923), methicillin-resistant Staphylococcus aureus (MSRA, ATCC 43300) and clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE 287), in vitro. HACC in the multilayer was released slowly with the degradation of the coating under the action of collagenase, further killing the planktonic bacteria, while the remaining HACC could kill the colonized bacteria. In a rat model of femur implants, the HACC-based multilayer-modified TCs effectively controlled the infection caused by MRSA and prevented bone destruction. Therefore, the HACC-based multilayer modified TCs with multiple antimicrobial properties could be a new potential ideal surface modification strategy to prevent implant associated infections.
WOS研究方向	Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/27264]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Ao, Haiyong,Yang, Shengbing,Nie, Bin'en,et al. Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(11):1951.
APA	Ao, Haiyong.,Yang, Shengbing.,Nie, Bin'en.,Fan, Qiming.,Zhang, Quanchao.,...&Tang, Tingting.(2019).Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions.JOURNAL OF MATERIALS CHEMISTRY B,7(11),1951.
MLA	Ao, Haiyong,et al."Improved antibacterial properties of collagen I/hyaluronic acid/quaternized chitosan multilayer modified titanium coatings with both contact-killing and release-killing functions".JOURNAL OF MATERIALS CHEMISTRY B 7.11(2019):1951.