Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles

doi:10.1016/j.chempr.2019.06.003

	Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles
	Zhang, Meng; Song, Ruixue; Liu, Yanyan; Yi, Zhigao; Meng, Xianfu; Zhang, Jiawen; Tang, Zhongmin; Yao, Zhenwei; Liu, Yang; Liu, Xiaogang
刊名	CHEM
	2019-08-08
卷号	5 期号:8 页码:2171
ISSN号	2451-9294
DOI	10.1016/j.chempr.2019.06.003
文献子类	Article
英文摘要	Calcium overload, characterized by an abnormal cytoplasm accumulation of free calcium ions (Ca2+), is a widely recognized cause of damage in numerous cell types and even of cell death. This undesirable destructive process can become a new tool applicable to cancer treatment. Herein, on the basis of the unique biological effect of Ca2+ we demonstrate a highly efficient strategy for tumor therapy by utilizing pH-sensitive sodium-hyaluronate-modified calcium peroxide nanoparticles (SH-CaO2 NPs). These NPs create an artificial calcium overloading stress in tumor cells, which is responsible for cell death. Notably, the killing effect is not limited to tumor types or hypoxic cells, and normal cells are more tolerant of the adverse influence of NPs than tumor cells. The Ca2+ enrichment also increases the likelihood of tumor calcification, which could contribute to in vivo tumor inhibition and facilitate medical imaging to monitor the treatment efficacy.
WOS研究方向	Chemistry
语种	英语
出版者	CELL PRESS
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/26914]
专题	中国科学院上海硅酸盐研究所
推荐引用方式 GB/T 7714	Zhang, Meng,Song, Ruixue,Liu, Yanyan,et al. Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles[J]. CHEM,2019,5(8):2171.
APA	Zhang, Meng.,Song, Ruixue.,Liu, Yanyan.,Yi, Zhigao.,Meng, Xianfu.,...&Bu, Wenbo.(2019).Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles.CHEM,5(8),2171.
MLA	Zhang, Meng,et al."Calcium-Overload-Mediated Tumor Therapy by Calcium Peroxide Nanoparticles".CHEM 5.8(2019):2171.