Parallel group ICA plus ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia

doi:10.1002/hbm.24632

	Parallel group ICA plus ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia
	Qi, Shile 2,3; Sui, Jing4,5,6,7 ; Chen, Jiayu 2,3; Liu, Jingyu 2,3; Jiang, Rongtao4,5,6 ; Silva, Rogers 2,3; Iraji, Armin 2,3; Damaraju, Eswar 2,3; Salman, Mustafa 2,3; Lin, Dongdong 2,3
刊名	HUMAN BRAIN MAPPING
	2019-09-01
卷号	40 期号:13 页码:3795-3809
关键词	group independent component analysis multimodal fusion parallel independent component analysis schizophrenia subjects' variability temporal information
ISSN号	1065-9471
DOI	10.1002/hbm.24632
通讯作者	Sui, Jing(jing.sui@nlpr.ia.ac.cn) ; Calhoun, Vince D.(vcalhoun@gsu.edu)
英文摘要	There is growing evidence that rather than using a single brain imaging modality to study its association with physiological or symptomatic features, the field is paying more attention to fusion of multimodal information. However, most current multimodal fusion approaches that incorporate functional magnetic resonance imaging (fMRI) are restricted to second-level 3D features, rather than the original 4D fMRI data. This trade-off is that the valuable temporal information is not utilized during the fusion step. Here we are motivated to propose a novel approach called "parallel group ICA+ICA" that incorporates temporal fMRI information from group independent component analysis (GICA) into a parallel independent component analysis (ICA) framework, aiming to enable direct fusion of first-level fMRI features with other modalities (e.g., structural MRI), which thus can detect linked functional network variability and structural covariations. Simulation results show that the proposed method yields accurate intermodality linkage detection regardless of whether it is strong or weak. When applied to real data, we identified one pair of significantly associated fMRI-sMRI components that show group difference between schizophrenia and controls in both modalities, and this linkage can be replicated in an independent cohort. Finally, multiple cognitive domain scores can be predicted by the features identified in the linked component pair by our proposed method. We also show these multimodal brain features can predict multiple cognitive scores in an independent cohort. Overall, results demonstrate the ability of parallel GICA+ICA to estimate joint information from 4D and 3D data without discarding much of the available information up front, and the potential for using this approach to identify imaging biomarkers to study brain disorders.
资助项目	Beijing Municipal Science and Technology Commission[Z181100001518005] ; Natural Science Foundation of China[61773380] ; Natural Science Foundation of China[81471367] ; NIH[1R01MH094524] ; NIH[P20GM103472] ; NIH[P30GM122734] ; NIH[R01EB005846] ; NIH[R56MH117107] ; National Science Foundation (NSF)[1539067] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB03040100]
WOS关键词	INDEPENDENT COMPONENT ANALYSIS ; GRAY-MATTER ABNORMALITIES ; WORKING-MEMORY ; FMRI DATA ; MULTIMODAL FUSION ; CONNECTIVITY ; METAANALYSIS ; DISORDER ; INFERENCES ; PREDICTION
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	WILEY
WOS记录号	WOS:000478645900007
资助机构	Beijing Municipal Science and Technology Commission ; Natural Science Foundation of China ; NIH ; National Science Foundation (NSF) ; Strategic Priority Research Program of the Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/27757]
专题	中国科学院自动化研究所
通讯作者	Sui, Jing; Calhoun, Vince D.
作者单位	1.Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA 2.Mind Res Network, Albuquerque, NM USA 3.Emory, Georgia Tech, Georgia State, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA 4.Brainnetome Ctr, Beijing 100190, Peoples R China 5.Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Beijing, Peoples R China 8.Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA 9.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA 10.Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA
推荐引用方式 GB/T 7714	Qi, Shile,Sui, Jing,Chen, Jiayu,et al. Parallel group ICA plus ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia[J]. HUMAN BRAIN MAPPING,2019,40(13):3795-3809.
APA	Qi, Shile.,Sui, Jing.,Chen, Jiayu.,Liu, Jingyu.,Jiang, Rongtao.,...&Calhoun, Vince D..(2019).Parallel group ICA plus ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia.HUMAN BRAIN MAPPING,40(13),3795-3809.
MLA	Qi, Shile,et al."Parallel group ICA plus ICA: Joint estimation of linked functional network variability and structural covariation with application to schizophrenia".HUMAN BRAIN MAPPING 40.13(2019):3795-3809.