Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder

doi:10.1007/s00330-019-06026-w

	Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder
	Liu, Yaou 1,2,3,4; Dong, Di5,6 ; Zhang, Liwen5,6 ; Zang, Yali5,6 ; Duan, Yunyun 1,2; Qiu, Xiaolu 4; Huang, Jing 4; Dong, Huiqing 7; Barkhof, Frederik 3,8; Hu, Chaoen5,6
刊名	EUROPEAN RADIOLOGY
	2019-09-01
卷号	29 期号:9 页码:4670-4677
关键词	Multiple sclerosis Neuromyelitis optica spectrum disorder Radiomics Nomogram Magnetic resonance imaging
ISSN号	0938-7994
DOI	10.1007/s00330-019-06026-w
通讯作者	Liu, Yaou(asiaeurope80@gmail.com) ; Tian, Jie(tian@ieee.org)
英文摘要	Objective To develop and validate an individual radiomics nomogram for differential diagnosis between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). Methods We retrospectively collected 67 MS and 68 NMOSD with spinal cord lesions as a primary cohort and prospectively recruited 28 MS and 26 NMOSD patients as a validation cohort. Radiomic features were extracted from the spinal cord lesions. A prediction model for differentiating MS and NMOSD was built by combining the radiomic features with several clinical and routine MRI measurements. The performance of the model was assessed with respect to its calibration plot and clinical discrimination in the primary and validation cohorts. Results Nine radiomics features extracted from an initial set of 485, predominantly reflecting lesion heterogeneity, combined with lesion length, patient sex, and EDSS, were selected to build the model for differentiating MS and NMOSD. The areas under the ROC curves (AUC) for differentiating the two diseases were 0.8808 and 0.7115, for the primary and validation cohort, respectively. This model demonstrated good calibration (C-index was 0.906 and 0.802 in primary and validation cohort). Conclusions A validated nomogram that incorporates the radiomic signature of spinal cord lesions, as well as cord lesion length, sex, and EDSS score, can usefully differentiate MS and NMOSD.
资助项目	ECTRIMS-MAGNMIS Fellowship from ECTRIMS ; National Science Foundation of China[81101038] ; National Science Foundation of China[81227901] ; National Science Foundation of China[81771924] ; National Science Foundation of China[81501736] ; National Science Foundation of China[61231004] ; National Science Foundation of China[81401377] ; National Science Foundation of China[81471221] ; National Science Foundation of China[81230028] ; National Basic Research Program of China[2013CB966900] ; National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFC1308700] ; National Key R&D Program of China[2017YFC1308701] ; Beijing Natural Science fund[7133244] ; Beijing Nova Programme[xx2013045] ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support[ZYLX201609] ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences[KFJ-SW-STS-160] ; Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period[2012BAI10B04]
WOS关键词	SPINAL-CORD ; BRAIN ; MRI ; FEATURES ; NOMOGRAM ; IMAGES ; SEX
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000478873300015
资助机构	ECTRIMS-MAGNMIS Fellowship from ECTRIMS ; National Science Foundation of China ; National Basic Research Program of China ; National Key R&D Program of China ; Beijing Natural Science fund ; Beijing Nova Programme ; Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support ; Science and Technology Service Network Initiative of the Chinese Academy of Sciences ; Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/27583]
专题	中国科学院自动化研究所
通讯作者	Liu, Yaou; Tian, Jie
作者单位	1.Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China 2.China Natl Clin Res Ctr Neurol Dis, Tiantan Image Res Ctr, Beijing 100050, Peoples R China 3.Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Neurosci Campus Amsterdam, NL-1007 MB Amsterdam, Netherlands 4.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 5.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 8.UCL, Inst Neurol & Healthcare Engn, London, England
推荐引用方式 GB/T 7714	Liu, Yaou,Dong, Di,Zhang, Liwen,et al. Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder[J]. EUROPEAN RADIOLOGY,2019,29(9):4670-4677.
APA	Liu, Yaou.,Dong, Di.,Zhang, Liwen.,Zang, Yali.,Duan, Yunyun.,...&Li, Kuncheng.(2019).Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder.EUROPEAN RADIOLOGY,29(9),4670-4677.
MLA	Liu, Yaou,et al."Radiomics in multiple sclerosis and neuromyelitis optica spectrum disorder".EUROPEAN RADIOLOGY 29.9(2019):4670-4677.