Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea

doi:10.1021/acs.orglett.9b02856

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	Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea
	Yan, Pengcheng 6; Li, Ge ; Wang, Chaojie ; Wu, Jianzhang 6; Sun, Zhongmin 5; Martin, Gary E.4; Wang, Xiao 3; Reibarkh, Mikhail 3; Sauri, Josep 2; Gustafson, Kirk R.1,6
刊名	ORGANIC LETTERS
	2019-09-20
卷号	21 期号:18 页码:7577-7581
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02856
通讯作者	Yan, Pengcheng(yanpc@wmu.edu.cn) ; Wu, Jianzhang(wujianzhang@wmu.edu.cn) ; Gustafson, Kirk R.(gustafki@mail.nih.gov)
英文摘要	The challenging structural motif of dictyospiromide (1), a spirosuccinimide alkaloid with antioxidant properties that are associated with activation of the Nrf2/ARE signaling pathway, was assigned using contemporary NMR experiments complemented with anisotropic NMR, chiroptical, and computational methodologies. Anisotropic NMR parameters provided critical orthogonal verification of the configuration of the difficult to assign spiro carbon and the other stereogenic centers in 1.
资助项目	Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; Natural Science Foundation of Zhejiang Province, China[Y19B020043] ; Public Project of Zhejiang Province[2017C37042] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707] ; Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000487577200081
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/162986]
专题	中国科学院海洋研究所
通讯作者	Yan, Pengcheng; Wu, Jianzhang; Gustafson, Kirk R.
作者单位	1.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD 21702 USA 2.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Boston, MA 02115 USA 3.Merck & Co Inc, Analyt Res & Dev, Struct Elucidat Grp, Rahway, NJ 07065 USA 4.Seton Hall Univ, Dept Chem & Biochem, S Orange, NJ 07079 USA 5.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Shandong, Peoples R China 6.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yan, Pengcheng,Li, Ge,Wang, Chaojie,et al. Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea[J]. ORGANIC LETTERS,2019,21(18):7577-7581.
APA	Yan, Pengcheng.,Li, Ge.,Wang, Chaojie.,Wu, Jianzhang.,Sun, Zhongmin.,...&Gustafson, Kirk R..(2019).Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea.ORGANIC LETTERS,21(18),7577-7581.
MLA	Yan, Pengcheng,et al."Characterization by Empirical and Computational Methods of Dictyospiromide, an Intriguing Antioxidant Alkaloid from the Marine Alga Dictyota coriacea".ORGANIC LETTERS 21.18(2019):7577-7581.