Translocation of tetrahedral DNA nanostructures through a solid-state nanopore

doi:10.1039/c8nr10474c

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Translocation of tetrahedral DNA nanostructures through a solid-state nanopore
	Zhao, XJ ; Ma, RP ; Hu, Y ; Chen, XY ; Dou, RF ; Liu, K ; Cui, CJ ; Liu, HJ ; Li, Q ; Pan, D
刊名	NANOSCALE
	2019
卷号	11 期号:13 页码:6263—6269
关键词	NUCLEIC-ACID NANOPARTICLES BIOSENSING INTERFACE TRANS LOCATION ORIGAMI PROTEIN MOLECULES VELOCITY CARRIERS
ISSN号	2040-3364
DOI	10.1039/c8nr10474c
文献子类	期刊论文
英文摘要	Tetrahedral DNA nanostructures (TDNs) are programmable DNA nanostructures that have great potential in bio-sensing, cell imaging and therapeutic applications. In this study, we investigate the translocation behavior of individual TDNs through solid-state nanopores. Pronounced translocation signals for TDNs are observed that are sensitive to the size of the nanostructures. TDNs bound to linear DNA molecules produce an extra signal in the ionic current traces. Statistical analysis of its relative temporal position reveals distinct features between TDNs bound to the end and those bound to the middle of the linear DNA molecules. A featured current trace for two TDNs bound to the same linear DNA molecule has also been observed. Our study demonstrates the potential of using TDNs as sensitive bio-sensors to detect specific segments of a single DNA molecule in real time, based on solid-state nanopore devices.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31884]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Condensed Matter Phys, Beijing 100190, Peoples R China; 2.Chinese Acad Sci, Inst Phys, Beijing 100190, Peoples R China; 3.Univ Chinese Acad Sci, Sch Phys Sci, Beijing 100190, Peoples R China; 4.Beijing Normal Univ, Beijing 100000, Peoples R China; 5.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; 6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China; 7.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facill,Div Phys Biol, Shanghai 201800, Peoples R China; 8.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Shanghai Synchrotron Radiat Facill,Bioimaging Ctr, Shanghai 201800, Peoples R China; 9.Shanghai Jiao Tong Univ, Bio X Inst, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Shanghai 200030, Peoples R China; 10.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China;
推荐引用方式 GB/T 7714	Zhao, XJ,Ma, RP,Hu, Y,et al. Translocation of tetrahedral DNA nanostructures through a solid-state nanopore[J]. NANOSCALE,2019,11(13):6263—6269.
APA	Zhao, XJ.,Ma, RP.,Hu, Y.,Chen, XY.,Dou, RF.,...&Lu, XH.(2019).Translocation of tetrahedral DNA nanostructures through a solid-state nanopore.NANOSCALE,11(13),6263—6269.
MLA	Zhao, XJ,et al."Translocation of tetrahedral DNA nanostructures through a solid-state nanopore".NANOSCALE 11.13(2019):6263—6269.