Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors

doi:10.1021/acs.nanolett.8b04051

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors
	Ye, DK ; Li, L ; Li, ZH ; Zhang, YY ; Li, M ; Shi, JY ; Wang, LH ; Fan, CH ; Yu, JH ; Zuo, XL
刊名	NANO LETTERS
	2019
卷号	19 期号:1 页码:369—374
关键词	BIOSENSING INTERFACE MICROFLUIDICS DIAGNOSTICS OPERATION PROTEINS DISEASES PLATFORM DEVICES STORAGE
ISSN号	1530-6984
DOI	10.1021/acs.nanolett.8b04051
文献子类	期刊论文
英文摘要	Molecular transport controls the efficiency of complex biological network systems such as cellular signaling system and cascade biomedical reaction. However, device fabrication for molecular sensing is often restricted by a low transport efficiency and complicated processing. Here, we report a molecular threading-dependent transport system using three-dimensional (3D) paper origami enabling the directional transport of biomolecules. We demonstrate that framework nucleic acid based interface engineering allows orthogonal molecular recognition and enzymatic reaction with programmed order on site. We thus develop a single-step electrochemical DNA sensor for quantitative analysis with 1 picomolar sensitivity within 60 min. Our sensor can discriminate a mismatched target at the level of a single base mismatch. Our study shows a great potential toward the development of a biomimetic molecular transport system for point-of-care and precision diagnosis.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31713]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200241, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200127, Peoples R China; 3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; 4.Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interficial Phys & Technol, Bioimaging Ctr,SSRF, Shanghai 201800, Peoples R China; 6.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Shandong, Peoples R China;
推荐引用方式 GB/T 7714	Ye, DK,Li, L,Li, ZH,et al. Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors[J]. NANO LETTERS,2019,19(1):369—374.
APA	Ye, DK.,Li, L.,Li, ZH.,Zhang, YY.,Li, M.,...&Zuo, XL.(2019).Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors.NANO LETTERS,19(1),369—374.
MLA	Ye, DK,et al."Molecular Threading-Dependent Mass Transport in Paper Origami for Single-Step Electrochemical DNA Sensors".NANO LETTERS 19.1(2019):369—374.