Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly

doi:10.1021/acsnano.8b08151

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly
	He, CJ ; Ye, TT ; Teng, WQ ; Fang, Z ; Ruan, WSY ; Liu, GW ; Chen, H ; Sun, JZ ; Hui, LL ; Sheng, F
刊名	ACS NANO
	2019
卷号	13 期号:2 页码:1910—1922
关键词	SINGLE-POLYMER DYNAMICS CHITOSAN FILMS GLYCOSAMINOGLYCANS FUNCTIONALIZATION FABRICATION ADHESION CHITIN CELLS
ISSN号	1936-0851
DOI	10.1021/acsnano.8b08151
文献子类	期刊论文
英文摘要	Layer-by-layer (LbL) assembly is widely applied as a coating technique for the nanoscale control of architecture and related properties. However, its translational applications are limited by the time-consuming and laborious nature of the process. Inspired by the blood-clotting process, herein, we develop a shear-flow-driven LbL (SF-LbL) self-assembly approach that accelerates the adsorption rate of macromolecules by mechanically configuring the polymer chain via a coil-stretch transition, which effectively simplifies and speeds the diffusion-controlled assembly process. The structural characteristics and surface homogeneity of the SF-LbL films are improved, and diverse three-dimensional structures can be achieved. Functional SF-LbL-assembled surfaces for corneal modification are successfully fabricated, and the surface of wounded rat corneas and skin can be directly decorated in situ with SF-LbL nanofilms due to the advantages of this approach. Furthermore, in situ SF-LbL self-assembly has promise as a simple approach for the wound dressing for interventional therapeutics in the clinic, as illustrated by the successful in situ fabrication of drug-free layers consisting of chitosan and heparin on the dorsal skin of diabetic mice to rescue defective wound healing. This bioinspired self-assembly approach is expected to provide a robust and versatile platform with which to explore the surface engineering of nanofilms in science, engineering, and medicine.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31490]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China; 2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Eye Ctr,Key Lab Ophthalmol Zhejiang Prov, Hangzhou 310009, Zhejiang, Peoples R China; 3.Zhejiang Univ, Inst Translat Med, Hangzhou 310029, Zhejiang, Peoples R China; 4.Zhejiang Univ, Dept Phys, Hangzhou 310027, Zhejiang, Peoples R China; 5.Zhejiang Univ, Dept Engn Mech, Key Lab Soft Machines & Smart Devices Zhejiang Pr, Hangzhou 310027, Zhejiang, Peoples R China; 6.Zhejiang Univ, Minist Educ, Key Lab Biomed Engn, Hangzhou 310009, Zhejiang, Peoples R China 7.Zhejiang Univ, Sch Med,Affiliated Hosp 2, Key Lab Canc Prevent & Intervent, Canc Inst,China Natl Minist Educ, Hangzhou 310009, Zhejiang, Peoples R China;
推荐引用方式 GB/T 7714	He, CJ,Ye, TT,Teng, WQ,et al. Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly[J]. ACS NANO,2019,13(2):1910—1922.
APA	He, CJ.,Ye, TT.,Teng, WQ.,Fang, Z.,Ruan, WSY.,...&Wang, B.(2019).Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly.ACS NANO,13(2),1910—1922.
MLA	He, CJ,et al."Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly".ACS NANO 13.2(2019):1910—1922.