Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA

doi:10.1021/acsnano.8b02864

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA
	Lai, W ; Ren, L ; Tang, Q ; Qu, XM ; Li, J ; Wang, LH ; Li, L ; Fan, CH ; Pei, H
刊名	ACS NANO
	2018
卷号	12 期号:7 页码:7093-7099
关键词	STRAND-DISPLACEMENT-REACTIONS NUCLEIC-ACID NANOSTRUCTURES RATIONAL DESIGN TOEHOLD HYBRIDIZATION KINETICS NANOTECHNOLOGY COMPUTATION CASCADES CIRCUIT
ISSN号	1936-0851
DOI	10.1021/acsnano.8b02864
文献子类	期刊论文
英文摘要	The programmable regulation of chemical reaction networks (CRNs) represents a major challenge toward the development of complex molecular devices performing sophisticated motions and functions. Nevertheless, regulation of artificial CRNs is generally energy and time-intensive as compared to natural regulation. Inspired by allosteric regulation in biological CRNs, we herein develop an intramolecular conformational motion strategy (InCMS) for programmable regulation of DNA CRNs. We design a DNA switch as the regulatory element to program the distance between the toehold and branch migration domain. The presence of multiple conformational transitions leads to wide-range kinetic regulation spanning over 4 orders of magnitude. Furthermore, the process of energy-cost-free strand exchange accompanied by conformational change discriminates single base mismatches. Our strategy thus provides a simple yet effective approach for dynamic programming of complex CRNs.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31076]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China 2.East China Normal Univ, Shanghai Key Lab Green Chem & Chem Proc, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China 5.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Lai, W,Ren, L,Tang, Q,et al. Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA[J]. ACS NANO,2018,12(7):7093-7099.
APA	Lai, W.,Ren, L.,Tang, Q.,Qu, XM.,Li, J.,...&Pei, H.(2018).Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA.ACS NANO,12(7),7093-7099.
MLA	Lai, W,et al."Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA".ACS NANO 12.7(2018):7093-7099.