Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production

doi:10.1039/c8nr04064h

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production
	Liu, S ; Cao, ST ; Guo, JY ; Luo, LQ ; Zhou, Y ; Lin, CL ; Shi, JY ; Fan, CH ; Lv, M ; Wang, LH
刊名	NANOSCALE
	2018
卷号	10 期号:41 页码:19603-19611
关键词	ANTIBACTERIAL ACTIVITY NANOPARTICLE BACTERIA MECHANISMS RESISTANCE NANOMATERIALS COMPOSITES NANOSHEETS EVOLUTION TOXICITY
ISSN号	2040-3364
DOI	10.1039/c8nr04064h
文献子类	期刊论文
英文摘要	Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of an antibacterial graphene oxide-silver nanoparticles (GO-AgNPs) composite on Pseudomonas aeruginosa biofilm formation. We found that GO-AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 g mL(-1). Interestingly, the bacterial biomass significantly decreased, but extracellular polymeric substance (EPS) production remarkably increased in mature biofilms treated with GO-AgNPs of an appropriate concentration, suggesting that GO-AgNPs effectively modulate biofilm development and structure. Moreover, we established that GO-AgNPs caused bacterial death via both physical damage and oxidative stress, showing the synergic action of GO and AgNPs. These findings facilitate the use of graphene-based nanocomposites for greener antibiotic applications.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/30959]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chengdu Univ Tradit Chinese Med, Sch Basic Med, Chengdu 611137, Sichuan, Peoples R China 2.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China 3.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Div Phys Biol, Shanghai 201800, Peoples R China 4.Chinese Acad Sci, Shanghai Synchrotron Radiat Facil, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr,Div Phys Biol, Shanghai 201800, Peoples R China 5.UCB Pharma, Slough SL1 3WE, Berks, England
推荐引用方式 GB/T 7714	Liu, S,Cao, ST,Guo, JY,et al. Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production[J]. NANOSCALE,2018,10(41):19603-19611.
APA	Liu, S.,Cao, ST.,Guo, JY.,Luo, LQ.,Zhou, Y.,...&Wang, LH.(2018).Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production.NANOSCALE,10(41),19603-19611.
MLA	Liu, S,et al."Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production".NANOSCALE 10.41(2018):19603-19611.